A new era of mutation rate analyses: Concepts and methods.
Zool Res
; 45(4): 767-780, 2024 Jul 18.
Article
en En
| MEDLINE
| ID: mdl-38894520
ABSTRACT
The mutation rate is a pivotal biological characteristic, intricately governed by natural selection and historically garnering considerable attention. Recent advances in high-throughput sequencing and analytical methodologies have profoundly transformed our understanding in this domain, ushering in an unprecedented era of mutation rate research. This paper aims to provide a comprehensive overview of the key concepts and methodologies frequently employed in the study of mutation rates. It examines various types of mutations, explores the evolutionary dynamics and associated theories, and synthesizes both classical and contemporary hypotheses. Furthermore, this review comprehensively explores recent advances in understanding germline and somatic mutations in animals and offers an overview of experimental methodologies, mutational patterns, molecular mechanisms, and driving forces influencing variations in mutation rates across species and tissues. Finally, it proposes several potential research directions and pressing questions for future investigations.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tasa de Mutación
Límite:
Animals
Idioma:
En
Revista:
Zool Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China