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Improved Positron Emission Tomography Quantification: Evaluation of a Maximum-Likelihood Scatter Scaling Algorithm.
Overbeck, Nanna; Ahangari, Sahar; Conti, Maurizio; Panin, Vladimir; Azam, Aleena; Kurbegovic, Sorel; Kjær, Andreas; Højgaard, Liselotte; Korsholm, Kirsten; Fischer, Barbara Malene; Andersen, Flemming Littrup; Andersen, Thomas Lund.
Afiliación
  • Overbeck N; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Ahangari S; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Conti M; Siemens Medical Solutions Inc., Knoxville, TN 37932, USA.
  • Panin V; Siemens Medical Solutions Inc., Knoxville, TN 37932, USA.
  • Azam A; Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Kurbegovic S; Department of Biomedical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
  • Kjær A; Department of Neurosurgery, Neuroscience Center, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Højgaard L; Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Korsholm K; Department of Biomedical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
  • Fischer BM; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Andersen FL; Cluster for Molecular Imaging, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
  • Andersen TL; Department of Biomedical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
Diagnostics (Basel) ; 14(11)2024 May 22.
Article en En | MEDLINE | ID: mdl-38893602
ABSTRACT
Incorrect scatter scaling of positron emission tomography (PET) images can lead to halo artifacts, quantitative bias, or reconstruction failure. Tail-fitted scatter scaling (TFSS) possesses performance limitations in multiple cases. This study aims to investigate a novel method for scatter scaling maximum-likelihood scatter scaling (MLSS) in scenarios where TFSS tends to induce artifacts or are observed to cause reconstruction abortion. [68Ga]Ga-RGD PET scans of nine patients were included in cohort 1 in the scope of investigating the reduction of halo artifacts relative to the scatter estimation method. PET scans of 30 patients administrated with [68Ga]Ga-uPAR were included in cohort 2, used for an evaluation of the robustness of MLSS in cases where TFSS-integrated reconstructions are observed to fail. A visual inspection of MLSS-corrected images scored higher than TFSS-corrected reconstructions of cohort 1. The quantitative investigation near the bladder showed a relative difference in tracer uptake of up to 94.7%. A reconstruction of scans included in cohort 2 resulted in failure in 23 cases when TFSS was used. The lesion uptake values of cohort 2 showed no significant difference. MLSS is suggested as an alternative scatter-scaling method relative to TFSS with the aim of reducing halo artifacts and a robust reconstruction process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagnostics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diagnostics (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Suiza