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Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review.
Begagic, Emir; Beculic, Hakija; Dzidic-Krivic, Amina; Kadic Vukas, Samra; Hadzic, Semir; Mekic-Abazovic, Alma; Segalo, Sabina; Papic, Emsel; Muchai Echengi, Emmanuel; Pugonja, Ragib; Kasapovic, Tarik; Kavgic, Dalila; Nuhovic, Adem; Jukovic-Bihorac, Fatima; Duricic, Slavisa; Pojskic, Mirza.
Afiliación
  • Begagic E; Department of General Medicine, School of Medicine, University of Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Beculic H; Department of Neurosurgery, Cantonal Hospital Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Dzidic-Krivic A; Department of Anatomy, School of Medicine, University of Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Kadic Vukas S; Department of Neurology, Cantonal Hospital Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Hadzic S; Department of Neurology, Cantonal Hospital Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Mekic-Abazovic A; Department of Physiology, Faculty of Medicine, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  • Segalo S; Department of Oncology, Cantonal Hospital Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Papic E; Department of Laboratory Technologies, Faculty of Health Studies, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.
  • Muchai Echengi E; Department of Laboratory Technologies, Faculty of Health Studies, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.
  • Pugonja R; College of Health Sciences, School of Medicine, Kenyatta University, Nairobi 43844-00100, Kenya.
  • Kasapovic T; Department of Anatomy, School of Medicine, University of Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Kavgic D; Department of Physiology, Faculty of Medicine, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  • Nuhovic A; Department of Physiology, Faculty of Medicine, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina.
  • Jukovic-Bihorac F; Department of General Medicine, School of Medicine, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.
  • Duricic S; Department of Pathology, Cantonal Hospital Zenica, 72000 Zenica, Bosnia and Herzegovina.
  • Pojskic M; Department of Pathology, School of Medicine, University of Zenica, 72000 Zenica, Bosnia and Herzegovina.
Cancers (Basel) ; 16(11)2024 May 30.
Article en En | MEDLINE | ID: mdl-38893207
ABSTRACT

BACKGROUND:

The study aims to investigate the role of hypoxia-inducible factors (HIFs) in the development, progression, and therapeutic potential of glioblastomas.

METHODOLOGY:

The study, following PRISMA guidelines, systematically examined hypoxia and HIFs in glioblastoma using MEDLINE (PubMed), Web of Science, and Scopus. A total of 104 relevant studies underwent data extraction.

RESULTS:

Among the 104 studies, global contributions were diverse, with China leading at 23.1%. The most productive year was 2019, accounting for 11.5%. Hypoxia-inducible factor 1 alpha (HIF1α) was frequently studied, followed by hypoxia-inducible factor 2 alpha (HIF2α), osteopontin, and cavolin-1. Commonly associated factors and pathways include glucose transporter 1 (GLUT1) and glucose transporter 3 (GLUT3) receptors, vascular endothelial growth factor (VEGF), phosphoinositide 3-kinase (PI3K)-Akt-mechanistic target of rapamycin (mTOR) pathway, and reactive oxygen species (ROS). HIF expression correlates with various glioblastoma hallmarks, including progression, survival, neovascularization, glucose metabolism, migration, and invasion.

CONCLUSION:

Overcoming challenges such as treatment resistance and the absence of biomarkers is critical for the effective integration of HIF-related therapies into the treatment of glioblastoma with the aim of optimizing patient outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article Pais de publicación: Suiza