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Nrf2 Signaling Pathway as a Key to Treatment for Diabetic Dyslipidemia and Atherosclerosis.
Yi, Michelle; Toribio, Arvin John; Salem, Yusuf Muhammad; Alexander, Michael; Ferrey, Antoney; Swentek, Lourdes; Tantisattamo, Ekamol; Ichii, Hirohito.
Afiliación
  • Yi M; Department of Surgery, University of California Irvine, Irvine, CA 92697, USA.
  • Toribio AJ; Department of Surgery, University of California Irvine, Irvine, CA 92697, USA.
  • Salem YM; Department of Surgery, University of California Irvine, Irvine, CA 92697, USA.
  • Alexander M; Department of Surgery, University of California Irvine, Irvine, CA 92697, USA.
  • Ferrey A; Department of Medicine, University of California Irvine, Irvine, CA 92697, USA.
  • Swentek L; Department of Surgery, University of California Irvine, Irvine, CA 92697, USA.
  • Tantisattamo E; Department of Medicine, University of California Irvine, Irvine, CA 92697, USA.
  • Ichii H; Department of Surgery, University of California Irvine, Irvine, CA 92697, USA.
Int J Mol Sci ; 25(11)2024 May 27.
Article en En | MEDLINE | ID: mdl-38892018
ABSTRACT
Diabetes mellitus (DM) is a chronic endocrine disorder that affects more than 20 million people in the United States. DM-related complications affect multiple organ systems and are a significant cause of morbidity and mortality among people with DM. Of the numerous acute and chronic complications, atherosclerosis due to diabetic dyslipidemia is a condition that can lead to many life-threatening diseases, such as stroke, coronary artery disease, and myocardial infarction. The nuclear erythroid 2-related factor 2 (Nrf2) signaling pathway is an emerging antioxidative pathway and a promising target for the treatment of DM and its complications. This review aims to explore the Nrf2 pathway's role in combating diabetic dyslipidemia. We will explore risk factors for diabetic dyslipidemia at a cellular level and aim to elucidate how the Nrf2 pathway becomes a potential therapeutic target for DM-related atherosclerosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Aterosclerosis / Dislipidemias / Factor 2 Relacionado con NF-E2 Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Aterosclerosis / Dislipidemias / Factor 2 Relacionado con NF-E2 Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza