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BACH2: The Future of Induced T-Regulatory Cell Therapies.
Zwick, Daniel; Vo, Mai Tram; Shim, Young Jun; Reijonen, Helena; Do, Jeong-Su.
Afiliación
  • Zwick D; Frederick National Laboratory, Frederick, MD 21701, USA.
  • Vo MT; School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
  • Shim YJ; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Reijonen H; Department of Immunology and Theranostics, City of Hope, Duarte, CA 91010, USA.
  • Do JS; Department of Immunology and Theranostics, City of Hope, Duarte, CA 91010, USA.
Cells ; 13(11)2024 May 22.
Article en En | MEDLINE | ID: mdl-38891024
ABSTRACT
BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A picture is emerging that BACH2 may function as a master regulator of cell fate that is exquisitely sensitive to cell activation status. In particular, BACH2 plays a key role in stabilizing the phenotype and suppressive function of transforming growth factor-beta (TGF-ß)-derived human forkhead box protein P3 (FOXP3)+ inducible regulatory T cells (iTregs), a cell type that holds great clinical potential as a cell therapeutic for diverse inflammatory conditions. As such, BACH2 potentially could be targeted to overcome the instability of the iTreg phenotype and suppressive function that has hampered their clinical application. In this review, we focus on the role of BACH2 in T cell fate and iTreg function and stability. We suggest approaches to modulate BACH2 function that may lead to more stable and efficacious Treg cell therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Factores de Transcripción con Cremalleras de Leucina de Carácter Básico Límite: Animals / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Factores de Transcripción con Cremalleras de Leucina de Carácter Básico Límite: Animals / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza