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Genetic characteristics of chromosomally integrated carbapenemase gene (blaNDM-1) in isolates of Proteus mirabilis.
Wang, Qingyu; Dong, Kai; Liu, Xudong; Li, Wanxiang; Bian, Qianyu.
Afiliación
  • Wang Q; Department of Clinical Laboratory, Weifang People's Hospital, Weifang, China.
  • Dong K; Department of Emergency, Weifang People's Hospital, Weifang, China.
  • Liu X; Department of Clinical Laboratory, Weifang People's Hospital, Weifang, China.
  • Li W; Department of Clinical Laboratory, Weifang People's Hospital, Weifang, China.
  • Bian Q; Department of Hematology, Weifang People's Hospital, Weifang, China. 1033527976@qq.com.
BMC Microbiol ; 24(1): 216, 2024 Jun 19.
Article en En | MEDLINE | ID: mdl-38890647
ABSTRACT

OBJECTIVE:

This study aims to conduct an in-depth genomic analysis of a carbapenem-resistant Proteus mirabilis strain to uncover the distribution and mechanisms of its resistance genes.

METHODS:

The research primarily utilized whole-genome sequencing to analyze the genome of the Proteus mirabilis strain. Additionally, antibiotic susceptibility tests were conducted to evaluate the strain's sensitivity to various antibiotics, and related case information was collected to analyze the clinical distribution characteristics of the resistant strain.

RESULTS:

Study on bacterial strain WF3430 from a tetanus and pneumonia patient reveals resistance to multiple antibiotics due to extensive use. Whole-genome sequencing exposes a 4,045,480 bp chromosome carrying 29 antibiotic resistance genes. Two multidrug-resistant (MDR) gene regions, resembling Tn6577 and Tn6589, were identified (MDR Region 1 64.83 Kb, MDR Region 2 85.64 Kbp). These regions, consist of integrative and conjugative elements (ICE) structures, highlight the intricate multidrug resistance in clinical settings.

CONCLUSION:

This study found that a CR-PMI strain exhibits a unique mechanism for acquiring antimicrobial resistance genes, such as blaNDM-1, located on the chromosome instead of plasmids. According to the results, there is increasing complexity in the mechanisms of horizontal transmission of resistance, necessitating a comprehensive understanding and implementation of targeted control measures in both hospital and community settings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Proteus / Proteus mirabilis / Proteínas Bacterianas / Beta-Lactamasas / Pruebas de Sensibilidad Microbiana / Farmacorresistencia Bacteriana Múltiple / Secuenciación Completa del Genoma / Antibacterianos Límite: Humans Idioma: En Revista: BMC Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Proteus / Proteus mirabilis / Proteínas Bacterianas / Beta-Lactamasas / Pruebas de Sensibilidad Microbiana / Farmacorresistencia Bacteriana Múltiple / Secuenciación Completa del Genoma / Antibacterianos Límite: Humans Idioma: En Revista: BMC Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido