Your browser doesn't support javascript.
loading
Beyond Death: Unmasking the Intricacies of Apoptosis Escape.
Ergün, Sercan; Aslan, Senanur; Demir, Dilbeste; Kayaoglu, Sümeyye; Saydam, Mevsim; Keles, Yeda; Kolcuoglu, Damla; Taskurt Hekim, Neslihan; Günes, Sezgin.
Afiliación
  • Ergün S; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. sercanergun@msn.com.
  • Aslan S; Department of Multidisciplinary Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey. sercanergun@msn.com.
  • Demir D; Department of Multidisciplinary Molecular Medicine, Institute of Graduate Studies, Ondokuz Mayis University, Samsun, Turkey.
  • Kayaoglu S; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Saydam M; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Keles Y; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Kolcuoglu D; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Taskurt Hekim N; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
  • Günes S; Department of Medical Biology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.
Mol Diagn Ther ; 28(4): 403-423, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38890247
ABSTRACT
Apoptosis, or programmed cell death, maintains tissue homeostasis by eliminating damaged or unnecessary cells. However, cells can evade this process, contributing to conditions such as cancer. Escape mechanisms include anoikis, mitochondrial DNA depletion, cellular FLICE inhibitory protein (c-FLIP), endosomal sorting complexes required for transport (ESCRT), mitotic slippage, anastasis, and blebbishield formation. Anoikis, triggered by cell detachment from the extracellular matrix, is pivotal in cancer research due to its role in cellular survival and metastasis. Mitochondrial DNA depletion, associated with cellular dysfunction and diseases such as breast and prostate cancer, links to apoptosis resistance. The c-FLIP protein family, notably CFLAR, regulates cell death processes as a truncated caspase-8 form. The ESCRT complex aids apoptosis evasion by repairing intracellular damage through increased Ca2+ levels. Antimitotic agents induce mitotic arrest in cancer treatment but can lead to mitotic slippage and tetraploid cell formation. Anastasis allows cells to resist apoptosis induced by various triggers. Blebbishield formation suppresses apoptosis indirectly in cancer stem cells by transforming apoptotic cells into blebbishields. In conclusion, the future of apoptosis research offers exciting possibilities for innovative therapeutic approaches, enhanced diagnostic tools, and a deeper understanding of the complex biological processes that govern cell fate. Collaborative efforts across disciplines, including molecular biology, genetics, immunology, and bioinformatics, will be essential to realize these prospects and improve patient outcomes in diverse disease contexts.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Neoplasias Límite: Animals / Humans Idioma: En Revista: Mol Diagn Ther Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Nueva Zelanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Apoptosis / Neoplasias Límite: Animals / Humans Idioma: En Revista: Mol Diagn Ther Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Nueva Zelanda