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Stealth Nanocarriers in Cancer Therapy: a Comprehensive Review of Design, Functionality, and Clinical Applications.
Saadh, Mohamed J; Mustafa, Mohammed Ahmed; Kumar, Ashwani; Alamir, Hassan Thoulfikar A; Kumar, Abhishek; Khudair, Shaymaa Abdulhameed; Faisal, Ahmed; Alubiady, Mahmood Hasen Shuhata; Jalal, Sarah Salah; Shafik, Shafik Shaker; Ahmad, Irfan; Khry, Faeza A F; Abosaoda, Munther Kadhim.
Afiliación
  • Saadh MJ; Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan. msaadeh@meu.edu.jo.
  • Mustafa MA; Department of Medical Laboratory Technology, University of Imam Jaafar AL-Sadiq, Baghdad, Iraq.
  • Kumar A; Department of Life Sciences, School of Sciences, Jain (Deemed-to-be) University, Bengaluru, Karnataka, India.
  • Alamir HTA; Department of Pharmacy, Vivekananda Global University, Jaipur, Rajasthan, India.
  • Kumar A; Faculty of Pharmacy, Department of Pharmaceutics, University of Al-Ameed, Najaf, Iraq.
  • Khudair SA; School of Pharmacy-Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, 247341, Uttar Pradesh, India.
  • Faisal A; Department of Pharmacy, Arka Jain University, Jamshedpur, Jharkhand, 831001, India.
  • Alubiady MHS; Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
  • Jalal SS; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq.
  • Shafik SS; Department of Pharmacy, Al-Hadi University College, Baghdad, 10011, Iraq.
  • Ahmad I; College of Pharmacy, National University of Science and Technology, Nasiriyah, Dhi Qar, Iraq.
  • Khry FAF; Experimental Nuclear Radiation Group, Scientific Research Center, Al-Ayen University, Thi-Qar, Iraq.
  • Abosaoda MK; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
AAPS PharmSciTech ; 25(6): 140, 2024 Jun 18.
Article en En | MEDLINE | ID: mdl-38890191
ABSTRACT
Nanotechnology has significantly transformed cancer treatment by introducing innovative methods for delivering drugs effectively. This literature review provided an in-depth analysis of the role of nanocarriers in cancer therapy, with a particular focus on the critical concept of the 'stealth effect.' The stealth effect refers to the ability of nanocarriers to evade the immune system and overcome physiological barriers. The review investigated the design and composition of various nanocarriers, such as liposomes, micelles, and inorganic nanoparticles, highlighting the importance of surface modifications and functionalization. The complex interaction between the immune system, opsonization, phagocytosis, and the protein corona was examined to understand the stealth effect. The review carefully evaluated strategies to enhance the stealth effect, including surface coating with polymers, biomimetic camouflage, and targeting ligands. The in vivo behavior of stealth nanocarriers and their impact on pharmacokinetics, biodistribution, and toxicity were also systematically examined. Additionally, the review presented clinical applications, case studies of approved nanocarrier-based cancer therapies, and emerging formulations in clinical trials. Future directions and obstacles in the field, such as advancements in nanocarrier engineering, personalized nanomedicine, regulatory considerations, and ethical implications, were discussed in detail. The review concluded by summarizing key findings and emphasizing the transformative potential of stealth nanocarriers in revolutionizing cancer therapy. This review enhanced the comprehension of nanocarrier-based cancer therapies and their potential impact by providing insights into advanced studies, clinical applications, and regulatory considerations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Portadores de Fármacos / Nanopartículas / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: AAPS PharmSciTech Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Portadores de Fármacos / Nanopartículas / Neoplasias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: AAPS PharmSciTech Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Estados Unidos