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Fibrosis-4 score for screening of metabolic dysfunction-associated steatotic liver disease (MASLD): Data from a population-based sample in Tuscany.
Silverii, Giovanni Antonio; Profili, Francesco; Francesconi, Paolo; Mannucci, Edoardo.
Afiliación
  • Silverii GA; Experimental and Clinical Biomedical Sciences "Mario Serio" Department, University of Florence Careggi Hospital, Diabetology Unit Largo Brambilla 3, 50134, Florence, Italy. Electronic address: giovanniantonio.silverii@unifi.it.
  • Profili F; Tuscany Regional Health Agency, Epidemiology Observatory, Italy.
  • Francesconi P; Tuscany Regional Health Agency, Epidemiology Observatory, Italy.
  • Mannucci E; Experimental and Clinical Biomedical Sciences "Mario Serio" Department, University of Florence Careggi Hospital, Diabetology Unit Largo Brambilla 3, 50134, Florence, Italy.
Nutr Metab Cardiovasc Dis ; 34(10): 2405-2408, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38890093
ABSTRACT
BACKGROUND AND

AIM:

To verify the prevalence of positive Fibrosis-4 (FIB-4) score, a screening test for metabolic-associated liver disease, in a large population-based sample in the Tuscany Italian Region, and to identify sub-populations at higher risk which could be targeted by specific screening programs. METHODS AND

RESULTS:

Population-based survey performed in the Italian region of Tuscany, with Tuscany health informative system's administrative data. We included 594,923 subjects, of which 32% had available data for the FIB-4 calculation. The overall proportion of subjects with an FIB-4 value > 1.3, was 41.6% of those with available exams, and 12,8% of the whole population, whereas 5.4% and 1.7% had FIB-4 >2.67. In those younger than 80 years, FIB >1.3 had a 33.1% and 9.4%. People with diabetes mellitus had higher figures (52.8.% and 28.9% for FIB>1.3). Among subjects aged 70 years or over, 74.9% of those with available data and 38.4% of the general population had a FIB-4>1.3, whereas 32% and 16% had a FIB-4 > 2.

CONCLUSIONS:

The relevant proportion of FIB-4 positivity in the general population poses a significant burden for further screening with liver elastography. Targeting people with diabetes, excluding people older than 80 years and/or adopting a FIB-4 threshold of 2 in those aged more than 70 years could increase the cost-effectiveness of the screening procedures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Valor Predictivo de las Pruebas / Enfermedad del Hígado Graso no Alcohólico Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Valor Predictivo de las Pruebas / Enfermedad del Hígado Graso no Alcohólico Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nutr Metab Cardiovasc Dis Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos