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Depressed patients with childhood maltreatment display altered intra- and inter-network resting state functional connectivity.
Gálber, Mónika; Anett Nagy, Szilvia; Orsi, Gergely; Perlaki, Gábor; Simon, Maria; Czéh, Boldizsár.
Afiliación
  • Gálber M; Neurobiology of Stress Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary.
  • Anett Nagy S; Neurobiology of Stress Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; HUN-REN-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary; Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Pécs Diagnostic Centre, Pécs, Hungary.
  • Orsi G; HUN-REN-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary; Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Pécs Diagnostic Centre, Pécs, Hungary; Department of Neurology, Medical School, University of Pécs, Hungary.
  • Perlaki G; HUN-REN-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary; Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Pécs Diagnostic Centre, Pécs, Hungary; Department of Neurology, Medical School, University of Pécs, Hungary.
  • Simon M; Neurobiology of Stress Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Department of Psychiatry and Psychotherapy, Medical School, University of Pécs, Hungary.
  • Czéh B; Neurobiology of Stress Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary. Electronic address: czeh.boldizsar@pte.hu.
Neuroimage Clin ; 43: 103632, 2024 Jun 12.
Article en En | MEDLINE | ID: mdl-38889524
ABSTRACT

BACKGROUND:

Childhood maltreatment (CM) is a major risk factor for the development of major depressive disorder (MDD). To gain more knowledge on how adverse childhood experiences influence the development of brain architecture, we studied functional connectivity (FC) alterations of neural networks of depressed patients with, or without the history of CM.

METHODS:

Depressed patients with severe childhood maltreatment (n = 18), MDD patients without maltreatment (n = 19), and matched healthy controls (n = 20) were examined with resting state functional MRI. History of maltreatment was assessed with the 28-item Childhood Trauma Questionnaire. Intra- and inter-network FC alterations were evaluated using FMRIB Software Library and CONN toolbox.

RESULTS:

We found numerous intra- and inter-network FC alterations between the maltreated and the non-maltreated patients. Intra-network FC differences were found in the default mode, visual and auditory networks, and cerebellum. Network modelling revealed several inter-network FC alterations connecting the default mode network with the executive control, salience and cerebellar networks. Increased inter-network FC was found in maltreated patients between the sensory-motor and visual, cerebellar, default mode and salience networks.

LIMITATIONS:

Relatively small sample size, cross-sectional design, and retrospective self-report questionnaire to assess adverse childhood experiences.

CONCLUSIONS:

Our findings confirm that severely maltreated depressed patients display numerous alterations of intra- and inter-network FC strengths, not only in their fronto-limbic circuits, but also in sensory-motor, visual, auditory, and cerebellar networks. These functional alterations may explain that maltreated individuals typically display altered perception and are prone to develop functional neurological symptom disorder (conversion disorder) in adulthood.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuroimage Clin Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuroimage Clin Año: 2024 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos