Your browser doesn't support javascript.
loading
The neurovascular unit and its correlation with cognitive performance in patients with cerebral small vessel disease: a canonical correlation analysis approach.
van Dinther, Maud; Voorter, Paulien H M; Zhang, Eleana; van Kuijk, Sander M J; Jansen, Jacobus F A; van Oostenbrugge, Robert J; Backes, Walter H; Staals, Julie.
Afiliación
  • van Dinther M; Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands. maud.van.dinther@mumc.nl.
  • Voorter PHM; CARIM-School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands. maud.van.dinther@mumc.nl.
  • Zhang E; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
  • van Kuijk SMJ; MHeNs-School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
  • Jansen JFA; Department of Neurology, Maastricht University Medical Center, Maastricht, The Netherlands.
  • van Oostenbrugge RJ; Department of Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University, Maastricht, the Netherlands.
  • Backes WH; Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
  • Staals J; MHeNs-School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Geroscience ; 46(5): 5061-5073, 2024 Oct.
Article en En | MEDLINE | ID: mdl-38888875
ABSTRACT
Growing evidence indicates an important role of neurovascular unit (NVU) dysfunction in the pathophysiology of cerebral small vessel disease (cSVD). Individually measurable functions of the NVU have been correlated with cognitive function, but a combined analysis is lacking. We aimed to perform a unified analysis of NVU function and its relation with cognitive performance. The relationship between NVU function in the white matter and cognitive performance (both latent variables composed of multiple measurable variables) was investigated in 73 patients with cSVD (mean age 70 ± 10 years, 41% women) using canonical correlation analysis. MRI-based NVU function measures included (1) the intravoxel incoherent motion derived perfusion volume fraction (f) and microvascular diffusivity (D*), reflecting cerebral microvascular flow; (2) the IVIM derived intermediate volume fraction (fint), indicative of the perivascular clearance system; and (3) the dynamic contrast-enhanced MRI derived blood-brain barrier (BBB) leakage rate (Ki) and leakage volume fraction (VL), reflecting BBB integrity. Cognitive performance was composed of 13 cognitive test scores. Canonical correlation analysis revealed a strong correlation between the latent variables NVU function and cognitive performance (r 0.73; p = 0.02). For the NVU, the dominating variables were D*, fint, and Ki. Cognitive performance was driven by multiple cognitive tests comprising different cognitive domains. The functionality of the NVU is correlated with cognitive performance in cSVD. Instead of focusing on individual pathophysiological mechanisms, future studies should target NVU dysfunction as a whole to acquire a coherent understanding of the complex disease mechanisms that occur in the NVU in cSVD.Trial registration NTR3786 (Dutch Trial Register).
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cognición / Enfermedades de los Pequeños Vasos Cerebrales Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cognición / Enfermedades de los Pequeños Vasos Cerebrales Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Geroscience Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza