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Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies.
Veronese, Nicola; Ragusa, Francesco Saverio; Sabico, Shaun; Dominguez, Ligia J; Barbagallo, Mario; Duque, Gustavo; Al-Daghri, Nasser.
Afiliación
  • Veronese N; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, 90127, Italy. nicola.veronese@unipa.it.
  • Ragusa FS; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. nicola.veronese@unipa.it.
  • Sabico S; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, 90127, Italy.
  • Dominguez LJ; Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • Barbagallo M; Department of Medicine and Surgery, Kore University of Enna, Enna, 94100, Italy.
  • Duque G; Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Palermo, 90127, Italy.
  • Al-Daghri N; Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Aging Clin Exp Res ; 36(1): 132, 2024 Jun 18.
Article en En | MEDLINE | ID: mdl-38888670
ABSTRACT
BACKGROUND &

AIMS:

Osteosarcopenia is a recently recognized geriatric syndrome. The association between osteosarcopenia and mortality risk is still largely underexplored. In this systematic review with meta-analysis of prospective cohort studies, we aimed to explore whether osteosarcopenia could be associated with a higher mortality risk.

METHODS:

Several databases were searched from the inception to 16th February 2024 for prospective cohort studies dealing with osteosarcopenia and mortality. We calculated the mortality risk in osteosarcopenia vs. controls using the most adjusted estimate available and summarized the data as risk ratios (RRs) with their 95% confidence intervals (CIs). A random-effect model was considered for all analyses.

RESULTS:

Among 231 studies initially considered, nine articles were included after exclusions for a total of 14,429 participants (mean age 70 years; 64.5% females). The weighted prevalence of osteosarcopenia was 12.72%. Over a mean follow-up of 6.6 years and after adjusting for a mean of four covariates, osteosarcopenia was associated with approximately 53% increased risk of mortality (RR 1.53; 95% CI 1.28-1.78). After accounting for publication bias, the re-calculated RR was 1.48 (95%CI 1.23-1.72). The quality of the studies was generally good, as determined by the Newcastle Ottawa Scale.

CONCLUSIONS:

Osteosarcopenia was significantly linked with an increased risk of mortality in older people, indicating the need to consider the presence of osteoporosis in patients with sarcopenia, and vice versa, since the combination of these two conditions typical of older people may lead to further complications, such as mortality.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcopenia Límite: Aged / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcopenia Límite: Aged / Female / Humans / Male Idioma: En Revista: Aging Clin Exp Res Asunto de la revista: GERIATRIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania