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Trajectories of squamous cell carcinoma antigen and outcomes of patients with advanced penile cancer after chemotherapy based on paclitaxel, ifosfamid, and cisplatin regimen.
Ma, Nan; Gan, Yi-Xiang; Chao, Yin-Yao; Liu, Zhen-Hua; Chen, Xian-Da; Yao, Kai; Han, Hui; Guo, Sheng-Jie.
Afiliación
  • Ma N; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Gan YX; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China.
  • Chao YY; Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, P.R. China.
  • Liu ZH; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Chen XD; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Yao K; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Han H; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Guo SJ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Cancer Med ; 13(12): e7353, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38888362
ABSTRACT

INTRODUCTION:

Penile cancer (PC) is a lethal malignancy with no effective prognostic biomarker. We aim to investigate associations between trajectories of squamous cell carcinoma antigen (SCC-A) and patient outcomes after chemotherapy based on paclitaxel, ifosfamid, and cisplatin (TIP) regimen.

METHODS:

Consecutive AJCC staging III/IV PC patients who received TIP chemotherapy and repeated SCC-A measurements in 2014-2022 were analyzed. Latent class growth mixed (LCGM) models were employed to characterize patients' serum SCC-A trajectories. Patient survival, and clinical and pathological tumor responses were compared. Inverse probability treatment weighting was used to adjust confounding factors.

RESULTS:

Eighty patients were included. LCGM models identified two distinct trajectories of SCC-A low-stable (40%; n = 32) and high-decline (60%; n = 48). Overall survival (HR [95% CI] 3.60 [1.23-10.53], p = 0.019), progression-free survival (HR [95% CI] 11.33 [3.19-40.3], p < 0.001), objective response rate (37.5% vs. 62.5% p = 0.028), disease control rate (60.4% vs. 96.9% p < 0.00), and pathological complete response rate (21.2% vs. 51.9%, p = 0.014) were significantly worse in the high-decline arm.

CONCLUSION:

PC patients' SCC-A change rate was associated with tumor response and patient survival after TIP chemotherapy. SCC-A might assist tumor monitoring after systemic therapies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Pene / Protocolos de Quimioterapia Combinada Antineoplásica / Serpinas / Cisplatino / Paclitaxel / Antígenos de Neoplasias Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Cancer Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Pene / Protocolos de Quimioterapia Combinada Antineoplásica / Serpinas / Cisplatino / Paclitaxel / Antígenos de Neoplasias Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Cancer Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos