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Effects of benzoic acid synthesized from Cinnamomum cassia by green chemistry on valproic acid-induced neurotoxicity in zebrafish embryos.
Cansiz, Derya; Özokan, Gökhan; Bilginer, Abdulkerim; Isikoglu, Semanur; Mizrak, Zülal; Ünal, Ismail; Beler, Merih; Alturfan, A Ata; Emekli-Alturfan, Ebru.
Afiliación
  • Cansiz D; Istanbul Medipol University, Faculty of Medicine, Medical Biochemistry, Istanbul, Türkiye.
  • Özokan G; BioArge Laboratories, Yildiz Technical University Technocity, Istanbul, Türkiye.
  • Bilginer A; BioArge Laboratories, Yildiz Technical University Technocity, Istanbul, Türkiye.
  • Isikoglu S; Department of Biochemistry, Institute of Health Sciences, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye.
  • Mizrak Z; Department of Biochemistry, Institute of Health Sciences, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye.
  • Ünal I; Department of Biochemistry, Institute of Health Sciences, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye.
  • Beler M; Department of Biochemistry, Institute of Health Sciences, Faculty of Pharmacy, Marmara University, Istanbul, Türkiye.
  • Alturfan AA; Department of Biochemistry, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
  • Emekli-Alturfan E; Department of Basic Medical Sciences, Faculty of Dentistry, Marmara University, Istanbul, Türkiye.
Toxicol Mech Methods ; 34(7): 833-843, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38888055
ABSTRACT
Benzoic acid, the most basic aromatic carboxylic acid, is produced industrially and used in cosmetic, hygiene, and pharmaceutical items as a flavoring ingredient and/or preservative. The significance of sodium benzoate, a metabolite of cinnamon, used as a food preservative and FDA-approved medication to treat urea cycle abnormalities in humans, has been shown to raise the levels of neurotrophic factors. Valproic acid (VPA), a commonly used anti-epileptic and mood-stabilizing medication, causes behavioral and intellectual problems and is a commonly used agent to induce animal model for autism. Aim of this study is to determine the effects of benzoic acid synthesized from Cinnamomum Cassia by green chemistry method on gene expressions related to autism development in case of VPA toxicity. Zebrafish embryos were exposed to low and high doses of benzoic acid for 72 h post-fertilization. Locomotor activities were determined. Acetylcholinesterase (AchE), lipid peroxidation, nitric oxide (NO), sialic acid (SA), glutathione (GSH)-S-transferase, catalase (CAT), and superoxide dismutase (SOD) activities were determined spectrophotometrically. eif4b, adsl, and shank3a expressions were determined by RT-PCR as autism-related genes. Although high-dose benzoic acid inhibited locomotor activity, benzoic acid at both doses ameliorated VPA-induced disruption in oxidant-antioxidant balance and inflammation in zebrafish embryos and was effective in improving the impaired expression of autism-related genes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Ácido Valproico / Ácido Benzoico / Cinnamomum aromaticum / Embrión no Mamífero / Tecnología Química Verde Límite: Animals Idioma: En Revista: Toxicol Mech Methods Asunto de la revista: TOXICOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pez Cebra / Ácido Valproico / Ácido Benzoico / Cinnamomum aromaticum / Embrión no Mamífero / Tecnología Química Verde Límite: Animals Idioma: En Revista: Toxicol Mech Methods Asunto de la revista: TOXICOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido