Adiposity in mares induces insulin dysregulation and mitochondrial dysfunction which can be mitigated by nutritional intervention.

Fresa, Kyle; Catandi, Giovana D; Whitcomb, Luke; Gonzalez-Castro, Raul A; Chicco, Adam J; Carnevale, Elaine M

Fresa, Kyle; Catandi, Giovana D; Whitcomb, Luke; Gonzalez-Castro, Raul A; Chicco, Adam J; Carnevale, Elaine M.

Afiliación

Fresa K; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Catandi GD; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Whitcomb L; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Gonzalez-Castro RA; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Chicco AJ; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA.
Carnevale EM; Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523, USA. elaine.carnevale@colostate.edu.

Sci Rep ; 14(1): 13992, 2024 06 18.

Article en En | MEDLINE | ID: mdl-38886475

ABSTRACT

ABSTRACT

Obesity is a complex disease associated with augmented risk of metabolic disorder development and cellular dysfunction in various species. The goal of the present study was to investigate the impacts of obesity on the metabolic health of old mares as well as test the ability of diet supplementation with either a complex blend of nutrients designed to improve equine metabolism and gastrointestinal health or L-carnitine alone to mitigate negative effects of obesity. Mares (n = 19, 17.9 ± 3.7 years) were placed into one of three group normal-weight (NW, n = 6), obese (OB, n = 7) or obese fed a complex diet supplement for 12 weeks (OBD, n = 6). After 12 weeks and completion of sample collections, OB mares received L-carnitine alone for an additional 6 weeks. Obesity in mares was significantly associated with insulin dysregulation, reduced muscle mitochondrial function, and decreased skeletal muscle oxidative capacity with greater ROS production when compared to NW. Obese mares fed the complex diet supplement had better insulin sensivity, greater cell lipid metabolism, and higher muscle oxidative capacity with reduced ROS production than OB. L-carnitine supplementation alone did not significantly alter insulin signaling, but improved lipid metabolism and muscle oxidative capacity with reduced ROS. In conclusion, obesity is associated with insulin dysregulation and altered skeletal muscle metabolism in older mares. However, dietary interventions are an effective strategy to improve metabolic status and skeletal muscle mitochondrial function in older mares.

Asunto(s)

Adiposidad; Carnitina; Suplementos Dietéticos; Insulina; Obesidad; Animales; Caballos; Femenino; Insulina/metabolismo; Insulina/sangre; Carnitina/metabolismo; Carnitina/farmacología; Obesidad/metabolismo; Obesidad/dietoterapia; Adiposidad/efectos de los fármacos; Mitocondrias/metabolismo; Mitocondrias/efectos de los fármacos; Músculo Esquelético/metabolismo; Músculo Esquelético/efectos de los fármacos; Metabolismo de los Lípidos/efectos de los fármacos; Enfermedades de los Caballos/metabolismo; Enfermedades de los Caballos/dietoterapia; Enfermedades de los Caballos/etiología; Resistencia a la Insulina; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

Equine; Insulin dysregulation; Metabolism; Mitochondrial dysfunction; Muscle; Obesity; Systemic

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carnitina / Suplementos Dietéticos / Adiposidad / Insulina / Obesidad Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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