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The impact of ZTE-based MR attenuation correction compared to CT-AC in 18F-FBPA PET before boron neutron capture therapy.
Lo, Yi-Wen; Lin, Ko-Han; Lee, Chien-Ying; Li, Chia-Wei; Lin, Chien-Yuan; Chen, Yi-Wei; Wang, Ling-Wei; Wu, Yuan-Hung; Huang, Wen-Sheng.
Afiliación
  • Lo YW; Integrated PET/MR Imaging Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan ROC.
  • Lin KH; Clinical Imaging Research Center (CIRC), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Lee CY; Integrated PET/MR Imaging Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan ROC. khlin1979@gmail.com.
  • Li CW; Integrated PET/MR Imaging Center, Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan ROC.
  • Lin CY; Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming Chiao Tung University, Taipei, Taiwan ROC.
  • Chen YW; GE Healthcare, Taipei, Taiwan ROC.
  • Wang LW; GE Healthcare, Taipei, Taiwan ROC.
  • Wu YH; Division of Radiotherapy, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan ROC.
  • Huang WS; Division of Radiotherapy, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan ROC.
Sci Rep ; 14(1): 13950, 2024 06 17.
Article en En | MEDLINE | ID: mdl-38886395
ABSTRACT
Tumor-to-normal ratio (T/N) measurement of 18F-FBPA is crucial for patient eligibility to receive boron neutron capture therapy. This study aims to compare the difference in standard uptake value ratios on brain tumors and normal brains using PET/MR ZTE and atlas-based attenuation correction with the current standard PET/CT attenuation correction. Regarding the normal brain uptake, the difference was not significant between PET/CT and PET/MR attenuation correction methods. The T/N ratio of PET/CT-AC, PET/MR ZTE-AC and PET/MR AB-AC were 2.34 ± 0.95, 2.29 ± 0.88, and 2.19 ± 0.80, respectively. The T/N ratio comparison showed no significance using PET/CT-AC and PET/MR ZTE-AC. As for the PET/MRI AB-AC, significantly lower T/N ratio was observed (- 5.18 ± 9.52%; p < 0.05). The T/N difference between ZTE-AC and AB-AC was also significant (4.71 ± 5.80%; p < 0.01). Our findings suggested PET/MRI imaging using ZTE-AC provided superior quantification on 18F-FBPA-PET compared to atlas-based AC. Using ZTE-AC on 18F-FBPA-PET /MRI might be crucial for BNCT pre-treatment planning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Imagen por Resonancia Magnética / Terapia por Captura de Neutrón de Boro / Tomografía Computarizada por Tomografía de Emisión de Positrones Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Imagen por Resonancia Magnética / Terapia por Captura de Neutrón de Boro / Tomografía Computarizada por Tomografía de Emisión de Positrones Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido