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Relationships between PET and blood plasma biomarkers in corticobasal syndrome.
Singh, Neha Atulkumar; Alnobani, Alla; Graff-Radford, Jonathan; Machulda, Mary M; Mielke, Michelle M; Schwarz, Christopher G; Senjem, Matthew L; Jack, Clifford R; Lowe, Val J; Kanekiyo, Takahisa; Josephs, Keith A; Whitwell, Jennifer L.
Afiliación
  • Singh NA; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Alnobani A; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  • Graff-Radford J; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Machulda MM; Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  • Mielke MM; Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina, USA.
  • Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Senjem ML; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Jack CR; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Kanekiyo T; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  • Josephs KA; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Whitwell JL; Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement ; 20(7): 4765-4774, 2024 07.
Article en En | MEDLINE | ID: mdl-38885334
ABSTRACT

INTRODUCTION:

Corticobasal syndrome (CBS) can result from underlying Alzheimer's disease (AD) pathologies. Little is known about the utility of blood plasma metrics to predict positron emission tomography (PET) biomarker-confirmed AD in CBS.

METHODS:

A cohort of eighteen CBS patients (8 amyloid beta [Aß]+; 10 Aß-) and 8 cognitively unimpaired (CU) individuals underwent PET imaging and plasma analysis. Plasma concentrations were compared using a Kruskal-Wallis test. Spearman correlations assessed relationships between plasma concentrations and PET uptake.

RESULTS:

CBS Aß+ group showed a reduced Aß42/40 ratio, with elevated phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) concentrations, while CBS Aß- group only showed elevated NfL concentration compared to CU. Both p-tau181 and GFAP were able to differentiate CBS Aß- from CBS Aß+ and showed positive associations with Aß and tau PET uptake.

DISCUSSION:

This study supports use of plasma p-tau181 and GFAP to detect AD in CBS. NfL shows potential as a non-specific disease biomarker of CBS regardless of underlying pathology. HIGHLIGHTS Plasma phosphorylated tau (p-tau)181 and glial fibrillary acidic protein (GFAP) concentrations differentiate corticobasal syndrome (CBS) amyloid beta (Aß)- from CBS Aß+. Plasma neurofilament light concentrations are elevated in CBS Aß- and Aß+ compared to controls. Plasma p-tau181 and GFAP concentrations were associated with Aß and tau positron emission tomography (PET) uptake. Aß42/40 ratio showed a negative correlation with Aß PET uptake.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Péptidos beta-Amiloides / Proteínas de Neurofilamentos / Proteínas tau / Tomografía de Emisión de Positrones / Proteína Ácida Fibrilar de la Glía Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Péptidos beta-Amiloides / Proteínas de Neurofilamentos / Proteínas tau / Tomografía de Emisión de Positrones / Proteína Ácida Fibrilar de la Glía Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos