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Racial differences in baroreflex function: Implications for the cardiovascular conundrum.
Williams, DeWayne P; Wiley, Cameron R; Birenbaum, Julia; Fishback, Grace M; Speller, Lassiter F; Koenig, Julian; Jarczok, Marc; Kapuku, Gaston; Reyes Del Paso, Gustavo A; Hill, LaBarron K; Thayer, Julian F.
Afiliación
  • Williams DP; Department of Psychological Science, University of California, Irvine, USA.
  • Wiley CR; Department of Psychological Science, University of California, Irvine, USA.
  • Birenbaum J; Department of Psychological Science, University of California, Irvine, USA.
  • Fishback GM; Department of Psychological Science, University of California, Irvine, USA.
  • Speller LF; Department of Psychology and Political Science, Eastern New Mexico University, Portales, NM, USA.
  • Koenig J; University of Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Germany.
  • Jarczok M; Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, Heidelberg University, Mannheim, Germany.
  • Kapuku G; Department of Medicine, Georgia Prevention Institute, Medical College of Georgia, Augusta University, Augusta, GA, USA.
  • Reyes Del Paso GA; Department of Psychology, University of Jaén, Jaén, Spain.
  • Hill LK; Department of Psychology, North Carolina Agricultural and Technical State University, Greensboro, NC, USA.
  • Thayer JF; Department of Psychological Science, University of California, Irvine, USA.
Am Heart J Plus ; 43: 100403, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38882590
ABSTRACT
Study

objective:

African Americans (AAs) show early signs of vascular dysfunction paired with elevated blood pressure (BP) and total peripheral resistance (TPR), which is thought to underlie their increased rates of cardiovascular health complications relative to European Americans (EAs). AAs paradoxically have higher cardiac vagal tone, indexed by heart rate variability (HRV), which is cardio-protective. This paradox has been termed the Cardiovascular Conundrum. The physiological mechanism underlying this phenomenon is not well understood. We examined race differences in baroreflex function, which might be an important mechanism underlying the Cardiovascular Conundrum.

Design:

Participants completed a 5-minute baseline period where resting cardiac metrics were assessed.

Setting:

Laboratory.

Participants:

130 college-aged individuals (54 women, 57 AAs). Main outcome

measures:

Baroreflex function was indexed as baroreflex sensitivity (BRS; the magnitude of changes in cardiovascular activity in accordance with BP changes) and effectiveness (BEI; the ratio of BP changes that elicit changes in cardiovascular activity) in the cardiac, vascular, and myocardial limbs. Results and

conclusions:

Results showed AAs to have higher HRV and cardiac BRS in comparison to EAs, suggesting the baroreflex is more sensitive to correcting the heart period for changes in BP among AAs compared to EAs. However, AAs showed lower vascular BEI relative to EAs, suggesting less effective control of TPR. In sum, lower BEI in the vascular branch might be an important mechanism underlying the Cardiovascular Conundrum (i.e., higher HRV and BP) and by extension, health disparities in cardiovascular diseases between AAs and EAs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am Heart J Plus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am Heart J Plus Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos