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Non-contrast-enhanced breast MRI for evaluation of tumor volume change after neoadjuvant chemotherapy.
Harada, Taiyo L; Uematsu, Takayoshi; Nakashima, Kazuaki; Sugino, Takashi; Nishimura, Seiichirou; Takahashi, Kaoru; Hayashi, Tomomi; Tadokoro, Yukiko.
Afiliación
  • Harada TL; Division of Breast Imaging and Breast Interventional Radiology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
  • Uematsu T; Division of Breast Imaging and Breast Interventional Radiology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan. Electronic address: t.uematsu@scchr.jp.
  • Nakashima K; Division of Breast Imaging and Breast Interventional Radiology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
  • Sugino T; Division of Pathology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
  • Nishimura S; Division of Breast Surgery, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
  • Takahashi K; Division of Breast Surgery, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
  • Hayashi T; Division of Breast Surgery, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
  • Tadokoro Y; Division of Breast Surgery, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan.
Eur J Radiol ; 177: 111555, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38880053
ABSTRACT

PURPOSE:

Three-dimensional contrast-enhanced magnetic resonance imaging (3D-Ce-MRI) is a most powerful tool for evaluation of neoadjuvant chemotherapy (NAC). However, the use of contrast agent is invasive, expensive, and time consuming, Thus, contrast agent-free imaging is preferable. We aimed to investigate the tumor volume change after NAC using maximum intensity projection diffusion-weighted image (MIP-DWI) and 3D-Ce-MRI.

METHOD:

We finally enrolled 55 breast cancer patients who underwent NAC in 2018. All MRI analyses were performed using SYNAPSE VINCENT® medical imaging system (Fujifilm Medical, Tokyo, Japan). We evaluated the tumor volumes before, during, and after NAC. Tumor volume before NAC on 3D-Ce-MRI was termed Pre-CE and those during and after NAC were termed Post-CE. The observer raised the lower end of the window width until the tumor was clearly visible and then manually deleted the non-tumor tissues. A month thereafter, the same observer who was blinded to the 3D-Ce-MRI results randomly evaluated the tumor volumes (Pre-DWI and Post-DWI) using MIP-DWI with the same method. Tumor volume change between ΔCE (Pre-CE - Post-CE/Pre-CE) and ΔDWI (Pre-DWI - Post-DWI/Pre-DWI) and the processing time for both methods (Time-DWI and Time-CE) were compared.

RESULTS:

We enrolled 55 patients. Spearman's rho between ΔDWI and ΔCE for pure mass lesions, and non-mass enhancement (NME) was 0.89 (p < 0.01), 0.63(p < 0.01) respectively. Time-DWI was significantly shorter than Time-CE (41.3 ± 21.2 and 199.5 ± 98.3 respectively, p < 0.01).

CONCLUSIONS:

Non-contrast-enhanced Breast MRI enables appropriate and faster evaluation of tumor volume change after NAC than 3D-Ce-MRI especially for mass lesions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Imagen por Resonancia Magnética / Terapia Neoadyuvante / Imagenología Tridimensional / Carga Tumoral Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Eur J Radiol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Imagen por Resonancia Magnética / Terapia Neoadyuvante / Imagenología Tridimensional / Carga Tumoral Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Eur J Radiol Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Irlanda