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Berberine, a natural alkaloid: Advances in its pharmacological effects and mechanisms in the treatment of autoimmune diseases.
Qin, Zhifang; Tang, Ran; Liang, Juan; Jia, Xiaoyi.
Afiliación
  • Qin Z; School of Pharmacy, Anhui University of Chinese Medicine, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei Anhui 230012, China.
  • Tang R; School of Pharmacy, Anhui University of Chinese Medicine, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei Anhui 230012, China.
  • Liang J; School of Pharmacy, Anhui University of Chinese Medicine, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei Anhui 230012, China.
  • Jia X; School of Pharmacy, Anhui University of Chinese Medicine, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei Anhui 230012, China; Anhui Province Key Laboratory of Research & Development of Chinese Medicine, Hefei Anhui 230012, China. Electronic address:
Int Immunopharmacol ; 137: 112422, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-38880024
ABSTRACT
The rising prevalence of autoimmune diseases poses a significant challenge to global public health. Continual exploration of natural compounds for effective treatments for autoimmune diseases is crucial. Berberine, a benzylisoquinoline alkaloid, is a bioactive component found in various medicinal plants, exhibiting diverse pharmacological properties. This review aims to consolidate the current understanding of berberine's pharmacological effects and mechanisms in addressing four autoimmune diseases rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and psoriasis. Overall, as a traditional Chinese medicinal preparation, berberine shows promise as an effective and safe treatment for autoimmune diseases. However, further comprehensive studies, particularly clinical trials, are essential to elucidate additional mechanisms and molecular targets, as well as to assess the efficacy and safety of berberine in treating these autoimmune diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Berberina Límite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Berberina Límite: Animals / Humans Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos