Chronic urticaria associated with Blastocystis hominis infection.

Jafari, Arya; Bahrami, Fares; Nasiri-Kalmarzi, Rasoul; Abdoli, Amir

Jafari, Arya; Bahrami, Fares; Nasiri-Kalmarzi, Rasoul; Abdoli, Amir.

Afiliación

Jafari A; Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Bahrami F; Zoonoses Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Nasiri-Kalmarzi R; Lung Diseases and Allergy Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. rasool_nsr@yahoo.com.
Abdoli A; Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran. a.abdoli25@gmail.com.

Arch Dermatol Res ; 316(7): 413, 2024 Jun 16.

Article en En | MEDLINE | ID: mdl-38879865

ABSTRACT

ABSTRACT

Urticaria is a skin rash with several etiologic factors, including infectious agents. Blastocystis hominis is an intestinal protozoan parasite that has been linked to urticaria and skin lesions. The aim of this work was to investigate the association between B. hominis infection and chronic urticaria. In a case-control study, stool samples were obtained from 94 patients with chronic urticaria as case group and 285 healthy individuals as control group. Urticaria activity score 7 (UAS7) was used to score the severity of urticaria, classified as mild, moderate and intense. All stool samples underwent routine stool examinations, as well as polymerase chain reaction (PCR) for the detection of B. hominis. Molecular detection was carried out using the small subunit ribosomal RNA (SSU-rRNA) gene and the parasite subtypes were determined by sequencing. The rate of B. hominis infection was 21.3% (20 out of 94) and 17.2% (49 out of 285) between the case and control groups, respectively (p = 0.463). Three subtypes of B. hominis, including ST-1, ST-2 and ST-3, were detected in the case and control groups (ST-1 = 30% vs. 8.3%, ST-2 = 40% vs. 25% and ST-3 = 30% vs. 66.6% in the case and control group, respectively), which was statistically significant (p = 0.00001). However, no statistical differences were found between the severity of the urticaria and the B. hominis subtypes (p = 0.533). This study revealed a higher prevalence (but not significant) of B. hominis infection among patients with urticaria than healthy individuals. However, the results did not find a significant association between the subtypes of B. hominis and the severity of urticaria.

Asunto(s)

Infecciones por Blastocystis; Blastocystis hominis; Urticaria Crónica; Heces; Humanos; Infecciones por Blastocystis/epidemiología; Infecciones por Blastocystis/complicaciones; Infecciones por Blastocystis/parasitología; Infecciones por Blastocystis/diagnóstico; Blastocystis hominis/aislamiento & purificación; Masculino; Femenino; Adulto; Estudios de Casos y Controles; Urticaria Crónica/parasitología; Urticaria Crónica/diagnóstico; Persona de Mediana Edad; Heces/parasitología; Adulto Joven; Índice de Severidad de la Enfermedad; Adolescente; Anciano; Urticaria/parasitología

Palabras clave

Blastocystis hominis; Chronic urticaria; Iran; Subtypes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por Blastocystis / Blastocystis hominis / Heces / Urticaria Crónica Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Dermatol Res Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Alemania

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