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Light regulates nuclear detainment of intron-retained transcripts through COP1-spliceosome to modulate photomorphogenesis.
Zhou, Hua; Zeng, Haiyue; Yan, Tingting; Chen, Sunlu; Fu, Ying; Qin, Guochen; Zhao, Xianhai; Heng, Yueqin; Li, Jian; Lin, Fang; Xu, Dongqing; Wei, Ning; Deng, Xing Wang.
Afiliación
  • Zhou H; Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Southern University of Science and Technology, Shenzhen, 518055, China.
  • Zeng H; Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences at Weifang, Weifang, 61000, Shandong, China.
  • Yan T; Peking-Tsinghua Center for Life Sciences, Peking University, 100871, Beijing, China.
  • Chen S; Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Southern University of Science and Technology, Shenzhen, 518055, China.
  • Fu Y; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, 210095, China.
  • Qin G; Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences at Weifang, Weifang, 61000, Shandong, China.
  • Zhao X; Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences at Weifang, Weifang, 61000, Shandong, China.
  • Heng Y; Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Southern University of Science and Technology, Shenzhen, 518055, China.
  • Li J; Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Southern University of Science and Technology, Shenzhen, 518055, China.
  • Lin F; Shenzhen Key Laboratory of Plant Genetic Engineering and Molecular Design, Southern University of Science and Technology, Shenzhen, 518055, China.
  • Xu D; Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, Lanzhou University, Lanzhou, 730000, China.
  • Wei N; State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing, 210095, China.
  • Deng XW; School of Life Sciences, Southwest University, Chongqing, 400715, China.
Nat Commun ; 15(1): 5130, 2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38879536
ABSTRACT
Intron retention (IR) is the most common alternative splicing event in Arabidopsis. An increasing number of studies have demonstrated the major role of IR in gene expression regulation. The impacts of IR on plant growth and development and response to environments remain underexplored. Here, we found that IR functions directly in gene expression regulation on a genome-wide scale through the detainment of intron-retained transcripts (IRTs) in the nucleus. Nuclear-retained IRTs can be kept away from translation through this mechanism. COP1-dependent light modulation of the IRTs of light signaling genes, such as PIF4, RVE1, and ABA3, contribute to seedling morphological development in response to changing light conditions. Furthermore, light-induced IR changes are under the control of the spliceosome, and in part through COP1-dependent ubiquitination and degradation of DCS1, a plant-specific spliceosomal component. Our data suggest that light regulates the activity of the spliceosome and the consequent IRT nucleus detainment to modulate photomorphogenesis through COP1.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intrones / Núcleo Celular / Empalmosomas / Arabidopsis / Regulación de la Expresión Génica de las Plantas / Proteínas de Arabidopsis / Ubiquitina-Proteína Ligasas / Luz Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intrones / Núcleo Celular / Empalmosomas / Arabidopsis / Regulación de la Expresión Génica de las Plantas / Proteínas de Arabidopsis / Ubiquitina-Proteína Ligasas / Luz Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido