Development and performance of an analytical method for polychlorinated naphthalenes and other persistent organic pollutants in dried blood spots.

Seo, Sung-Hee; Batterman, Stuart

Seo, Sung-Hee; Batterman, Stuart.

Afiliación

Seo SH; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, United States; School of Liberal Studies, Kunsan National University, 558 Daehak-ro, Gunsan, Jeollabuk-Do 54150, Republic of Korea.
Batterman S; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, United States. Electronic address: stuartb@umich.edu.

Anal Chim Acta ; 1315: 342756, 2024 Aug 01.

Article en En | MEDLINE | ID: mdl-38879204

ABSTRACT

ABSTRACT

BACKGROUND:

Dried blood spots (DBSs) collected and archived in newborn screening programs (NSP) represent a potentially valuable resource for assessing exposure to a range of organic and inorganic chemicals in newborns. This study develops and optimizes a method to measure polychlorinated naphthalenes (PCNs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) in DBS using the isotope dilution technique, ultrasonic-assisted liquid-liquid extraction, simple cleanup, triple quadrupole GC-MS/MS analysis, and background correction.

RESULTS:

We minimize the number of extraction repetitions and the volume of solvent, which helps increase throughput while minimizing the potential for contamination. We obtained high recovery and precision for most compounds, and method detection limits (MDLs) were sufficiently low to detect the more prevalent compounds based on representative sample of the US population. MDLs averaged 0.020 ng/mL (recovery 107 %, precision 4 %) for PCNs, 0.021 ng/mL (recovery 97 %, precision 4 %) for PCBs, 0.021 ng/mL (recovery 117 %, precision 2 %) for OCPs, and 0.021 ng/mL (recovery 96 %, precision 3 %) for PBDEs. SIGNIFICANCE AND NOVELTY To our knowledge, this is the first study presenting an analytical method and for PCNs in DBS, and one of the few studies providing an assessment of method performance for persistent organic pollutants in DBS. The optimized method can be applied to a wide range of applications, including exposure assessment, environmental epidemiology, forensics, environmental surveillance, and ecological monitoring.

Asunto(s)

Pruebas con Sangre Seca; Naftalenos; Contaminantes Orgánicos Persistentes; Espectrometría de Masas en Tándem; Pruebas con Sangre Seca/métodos; Humanos; Naftalenos/sangre; Contaminantes Orgánicos Persistentes/sangre; Espectrometría de Masas en Tándem/métodos; Éteres Difenilos Halogenados/sangre; Éteres Difenilos Halogenados/análisis; Bifenilos Policlorados/sangre; Bifenilos Policlorados/análisis; Extracción Líquido-Líquido/métodos; Hidrocarburos Clorados/sangre; Hidrocarburos Clorados/análisis; Recién Nacido; Cromatografía de Gases y Espectrometría de Masas/métodos; Límite de Detección; Plaguicidas/sangre; Plaguicidas/análisis

Palabras clave

Dried blood spots; Organochlorine pesticide; Polybrominated diphenyl ethers; Polychlorinated biphenyls; Polychlorinated naphthalenes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectrometría de Masas en Tándem / Pruebas con Sangre Seca / Contaminantes Orgánicos Persistentes / Naftalenos Límite: Humans / Newborn Idioma: En Revista: Anal Chim Acta Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

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