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Trajectory correction enables free-running chemical shift encoded imaging for accurate cardiac proton-density fat fraction quantification at 3T.
Daudé, Pierre; Troalen, Thomas; Mackowiak, Adèle L C; Royer, Emilien; Piccini, Davide; Yerly, Jérôme; Pfeuffer, Josef; Kober, Frank; Gouny, Sylviane Confort; Bernard, Monique; Stuber, Matthias; Bastiaansen, Jessica A M; Rapacchi, Stanislas.
Afiliación
  • Daudé P; Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France. Electronic address: pierre.daude@univ-amu.fr.
  • Troalen T; Siemens Healthcare SAS, Saint-Denis, France. Electronic address: thomas.troalen@siemens-healthineers.com.
  • Mackowiak ALC; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland; Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Translation Imaging Center (TIC), Swiss I
  • Royer E; Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France. Electronic address: emilien.royer@univ-amu.fr.
  • Piccini D; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland; Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland. Electronic address: davide.piccini@siemens-healthineers.com.
  • Yerly J; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland; Center for Biomedical Imaging, Lausanne, Switzerland. Electronic address: jerome.yerly@chuv.ch.
  • Pfeuffer J; Siemens Healthcare, MR Application Development, Erlangen, Germany. Electronic address: josef.pfeuffer@siemens-healthineers.com.
  • Kober F; Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France. Electronic address: frank.kober@univ-amu.fr.
  • Gouny SC; Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France. Electronic address: sylviane.gouny@univ-amu.fr.
  • Bernard M; Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France. Electronic address: monique.bernard@univ-amu.fr.
  • Stuber M; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland; Center for Biomedical Imaging, Lausanne, Switzerland. Electronic address: matthias.stuber@chuv.ch.
  • Bastiaansen JAM; Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Translation Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland.
  • Rapacchi S; Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France. Electronic address: stanislas.RAPACCHI@univ-amu.fr.
J Cardiovasc Magn Reson ; 26(2): 101048, 2024 Jun 13.
Article en En | MEDLINE | ID: mdl-38878970
ABSTRACT

BACKGROUND:

Metabolic diseases can negatively alter epicardial fat accumulation and composition, which can be probed using quantitative cardiac chemical shift encoded (CSE) cardiovascular magnetic resonance (CMR) by mapping proton-density fat fraction (PDFF). To obtain motion-resolved high-resolution PDFF maps, we proposed a free-running cardiac CSE-CMR framework at 3T. To employ faster bipolar readout gradients, a correction for gradient imperfections was added using the gradient impulse response function (GIRF) and evaluated on intermediate images and PDFF quantification.

METHODS:

Ten minutes free-running cardiac 3D radial CSE-CMR acquisitions were compared in vitro and in vivo at 3T. Monopolar and bipolar readout gradient schemes provided 8 echoes (TE1/ΔTE = 1.16/1.96 ms) and 13 echoes (TE1/ΔTE = 1.12/1.07 ms), respectively. Bipolar-gradient free-running cardiac fat and water images and PDFF maps were reconstructed with or without GIRF correction. PDFF values were evaluated in silico, in vitro on a fat/water phantom, and in vivo in 10 healthy volunteers and 3 diabetic patients.

RESULTS:

In monopolar mode, fat-water swaps were demonstrated in silico and confirmed in vitro. Using bipolar readout gradients, PDFF quantification was reliable and accurate with GIRF correction with a mean bias of 0.03% in silico and 0.36% in vitro while it suffered from artifacts without correction, leading to a PDFF bias of 4.9% in vitro and swaps in vivo. Using bipolar readout gradients, in vivo PDFF of epicardial adipose tissue was significantly lower compared to subcutaneous fat (80.4 ± 7.1% vs 92.5 ± 4.3%, P < 0.0001).

CONCLUSIONS:

Aiming for an accurate PDFF quantification, high-resolution free-running cardiac CSE-MRI imaging proved to benefit from bipolar echoes with k-space trajectory correction at 3T. This free-breathing acquisition framework enables to investigate epicardial adipose tissue PDFF in metabolic diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cardiovasc Magn Reson Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Cardiovasc Magn Reson Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA / DIAGNOSTICO POR IMAGEM Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido