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Long-Term Functional Limitations and Predictors of Recovery After COVID-19: A Multicenter Prospective Cohort Study.
Beauchamp, Marla; Kirkwood, Renata; Duong, MyLinh; Ho, Terence; Raina, Parminder; Kruisselbrink, Rebecca; Jones, Aaron; Girolametto, Carla; Costa, Andrew.
Afiliación
  • Beauchamp M; School of Rehabilitation Science, McMaster University, Hamilton, Ont, Canada. Electronic address: beaucm1@mcmaster.ca.
  • Kirkwood R; School of Rehabilitation Science, McMaster University, Hamilton, Ont, Canada.
  • Duong M; Department of Medicine, McMaster University, Hamilton, Ont, Canada; Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Ont, Canada.
  • Ho T; Department of Medicine, McMaster University, Hamilton, Ont, Canada; Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Ont, Canada.
  • Raina P; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont, Canada.
  • Kruisselbrink R; Department of Medicine, McMaster University, Hamilton, Ont, Canada.
  • Jones A; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont, Canada.
  • Girolametto C; Research, Innovation and Clinical Trials, Grand River Hospital, Kitchener, Ont, Canada.
  • Costa A; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ont, Canada.
Am J Med ; 2024 Jun 13.
Article en En | MEDLINE | ID: mdl-38878946
ABSTRACT

BACKGROUND:

Limited data exist on post-severe COVID-19 functional trajectory, particularly considering premorbid status. We characterized 1-year functional recovery post-hospitalization for COVID-19, highlighting predictors of long-term recovery.

METHODS:

We enrolled adult patients with lab-confirmed SARS-CoV-2 infection and hospitalized for COVID-19 sequelae, from five major Ontario, Canada hospitals in a prospective cohort study. Assessments included telephone interviews on admission followed by telephone and in-person assessments at 3-, 6-, 9-, and 12-months post-discharge. The Activity-Measure for Post-Acute Care (AM-PAC) Mobility and Cognition scales were administered at baseline and every 3 months for 1 year. Secondary outcomes included symptoms, spirometry, physical performance, dyspnea, fatigue, distress, anxiety and depression, and quality of life.

RESULTS:

A total of 254 patients (57.1% male) with a mean age of 60.0 (±13.1) years and an average hospital stay of 14.3 (±19.7) days agreed to participate. At 12 months, 55.3% demonstrated clinically important deficits in mobility and 38.8% had cognitive deficits compared to premorbid levels. Fatigue was reported in 44.2%, followed by difficulty walking long distances in 35.8% and dyspnea in 33.0%. Almost 40% of patients had an FEV1(% Pred) < 80% at 12 months, 60.3% had impairments in physical performance, and 44.5% had problems with anxiety or depression. Predictors of better mobility at 12 months included higher premorbid mobility status, male sex, shorter hospital stay, fewer comorbidities, and higher FEV1 (% pred) at the 3-month follow-up.

CONCLUSIONS:

Our study provides compelling evidence of the long-term impact of COVID-19 on functional and cognitive status 1-year post-infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Med Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos