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Anti-edematous effects of epinastine, cetirizine and its enantiomers in λ-carrageenan-induced edema in rat hind paw.
Taguchi, K; Chuang, V T G; Ozawa, M; Sakamoto, Y; Hara, R; Iketani, O; Enoki, Y; Kizu, J; Hori, S; Matsumoto, K.
Afiliación
  • Taguchi K; Division of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan.
  • Chuang VTG; Discipline of Pharmacy , Curtin Medical School, Faculty of Health Sciences, Curtin University, Perth, Australia.
  • Ozawa M; Division of Practical Pharmacy, Faculty of Pharmacy.
  • Sakamoto Y; Division of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan; Division of Practical Pharmacy, Faculty of Pharmacy.
  • Hara R; Division of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan; Division of Practical Pharmacy, Faculty of Pharmacy.
  • Iketani O; Division of Infectious Diseases and Infection Control , Keio University Hospital.
  • Enoki Y; Division of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan.
  • Kizu J; Division of Practical Pharmacy, Faculty of Pharmacy.
  • Hori S; Department of Infectious Diseases and Infection Control, Jikei University School of Medicine, Tokyo, Japan.
  • Matsumoto K; Division of Pharmacodynamics, Keio University Faculty of Pharmacy, Tokyo, Japan; Division of Practical Pharmacy, Faculty of Pharmacy.
Pharmazie ; 79(6): 98-100, 2024 Jun 01.
Article en En | MEDLINE | ID: mdl-38877684
ABSTRACT
Urticaria is induced by the histamine released from mast cells which develops wheals (edema) as a visual feature. In clinical practice, second-generation histamine H1 -receptor blockers are routinely used as the first-line symptomatic treatment for urticaria. Nevertheless, not much research has directly examined the second-generation histamine H1-receptor blockers' ability to reduce edema. In this study, we directly evaluated the anti-edematous activities of three second-generation histamine H1-receptor blockers available in the market (epinastine hydrochloride, cetirizine hydrochloride, and levocetirizine hydrochloride) using a λ-carrageenan-induced footpad edema model. One hour before the induction of edema with 1% λ -carrageenan injection, all second-generation histamine H1 -receptor blockers (5, 10, 50 and 100 mg/kg) were subcutaneously administered to rats. At 0.5 and 3 hours after λ -carrageenan administration, the edema volume was evaluated using a Plethysmometer. Epinastine hydrochloride significantly suppressed the edema growth in a dose-dependent manner. Cetirizine hydrochloride showed a slight anti-edematous effect, while levocetirizine significantly inhibited the development of edema in a dose-dependent manner. On the other hand, dextrocetirizine did not prevent edema from growing. In summary, second-generation histamine H1 -receptor blockers, at least those examined in this study, may be able to reduce the clinical symptoms of urticaria associated with edema. Levocetirizine hydrochloride is also anticipated to have stronger anti-edematous effects than cetirizine hydrochloride because levocetirizine is responsible for cetirizine's anti-edematous activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Cetirizina / Edema Límite: Animals Idioma: En Revista: Pharmazie Asunto de la revista: FARMACIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carragenina / Cetirizina / Edema Límite: Animals Idioma: En Revista: Pharmazie Asunto de la revista: FARMACIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania