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The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-omics Mendelian randomization study.
Lv, Chen-Xi; Zhou, Lin-Po; Yang, Ye-Bing; Shi, Jing; Dong, Fan-He; Wei, Hao-Ran; Shan, Yu-Qiang.
Afiliación
  • Lv CX; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
  • Zhou LP; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Westlake University, Hangzhou, Zhejiang, 310006, China.
  • Yang YB; Department of General Surgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, 310006, China.
  • Shi J; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
  • Dong FH; Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Westlake University, Hangzhou, Zhejiang, 310006, China.
  • Wei HR; Department of General Surgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, Zhejiang, 310006, China.
  • Shan YQ; The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, China.
BMC Gastroenterol ; 24(1): 197, 2024 Jun 14.
Article en En | MEDLINE | ID: mdl-38877387
ABSTRACT

BACKGROUND:

Innate/adaptive immunity is the key to anti-tumor therapy. However, its causal relationship to Gastrointestinal (GI) cancer remains unclear.

METHODS:

Immunity genes were extracted from the MSigDB database. The Genome-wide association studies (GWAS) summary data of GI cancer were integrated with expression quantitative trait loci (eQTL) and DNA methylation quantitative trait loci (mQTL) associated with genes. Summary-data-based Mendelian randomization (SMR) and co-localization analysis were used to reveal causal relationships between genes and GI cancer. Two-sample MR analysis was used for sensitivity analysis. Single cell analysis clarified the enrichment of genes.

RESULTS:

Three-step SMR analysis showed that a putative mechanism, cg17294865 CpG site regulating HLA-DRA expression was negatively associated with gastric cancer risk. HLA-DRA was significantly differentially expressed in monocyte/macrophage and myeloid cells in gastric cancer.

CONCLUSION:

This study provides evidence that upregulating the expression level of HLA-DRA can reduce the risk of gastric cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Sitios de Carácter Cuantitativo / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Inmunidad Adaptativa / Neoplasias Gastrointestinales / Inmunidad Innata Límite: Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metilación de ADN / Sitios de Carácter Cuantitativo / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Inmunidad Adaptativa / Neoplasias Gastrointestinales / Inmunidad Innata Límite: Humans Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido