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Association between antibody responses post-vaccination and severe COVID-19 outcomes in Scotland.
Macdonald, Calum; Palmateer, Norah; McAuley, Andrew; Lindsay, Laura; Hasan, Taimoor; Hameed, Safraj Shahul; Hall, Elliot; Jeffrey, Karen; Grange, Zoë; Gousias, Petros; Mavin, Sally; Jarvis, Lisa; Cameron, J Claire; Daines, Luke; Tibble, Holly; Simpson, Colin R; McCowan, Colin; Katikireddi, Srinivasa Vittal; Rudan, Igor; Fagbamigbe, Adeniyi Francis; Ritchie, Lewis; Swallow, Ben; Moss, Paul; Robertson, Chris; Sheikh, Aziz; Murray, Josie.
Afiliación
  • Macdonald C; Usher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK. calum.macdonald@hdruk.ac.uk.
  • Palmateer N; Health Data Research UK, Gibbs Building, 215 Euston Road, NW1 2BE, London, UK. calum.macdonald@hdruk.ac.uk.
  • McAuley A; School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens, Road, Glasgow, G4 0BA, UK. norah.palmateer@phs.scot.
  • Lindsay L; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK. norah.palmateer@phs.scot.
  • Hasan T; School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens, Road, Glasgow, G4 0BA, UK.
  • Hameed SS; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Hall E; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Jeffrey K; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Grange Z; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Gousias P; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Mavin S; Usher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.
  • Jarvis L; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Cameron JC; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Daines L; Scottish Microbiology Reference Laboratory, Raigmore Hospital, Old Perth Road, Inverness, IV2 3UJ, UK.
  • Tibble H; Scottish National Blood Transfusion Service, Jack Copland Centre, 52 Research Avenue North, EH14 4BE, Edinburgh, UK.
  • Simpson CR; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • McCowan C; Usher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.
  • Katikireddi SV; Usher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.
  • Rudan I; School of Health, Wellington Faculty of Health, Victoria University of Wellington, PO Box 600, Wellington, 6140, Wellington, New Zealand.
  • Fagbamigbe AF; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, UK.
  • Ritchie L; Public Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
  • Swallow B; MRC/CSO Social & Public Health Sciences Unit, University of Glasgow Berkeley Square, 99 Berkeley St., G3 7HR, Glasgow, UK.
  • Moss P; Usher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.
  • Robertson C; Institute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill Rd, AB25 2ZD, Aberdeen, UK.
  • Sheikh A; Centre of Academic Primary Care, University of Aberdeen, Polwarth Building, Foresterhill Rd, AB25 2ZD, Aberdeen, UK.
  • Murray J; School of Mathematics and Statistics, University of St Andrews, KY16 9SS, St Andrews, UK.
NPJ Vaccines ; 9(1): 107, 2024 Jun 14.
Article en En | MEDLINE | ID: mdl-38877008
ABSTRACT
Several population-level studies have described individual clinical risk factors associated with suboptimal antibody responses following COVID-19 vaccination, but none have examined multimorbidity. Others have shown that suboptimal post-vaccination responses offer reduced protection to subsequent SARS-CoV-2 infection; however, the level of protection from COVID-19 hospitalisation/death remains unconfirmed. We use national Scottish datasets to investigate the association between multimorbidity and testing antibody-negative, examining the correlation between antibody levels and subsequent COVID-19 hospitalisation/death among double-vaccinated individuals. We found that individuals with multimorbidity ( ≥ five conditions) were more likely to test antibody-negative post-vaccination and 13.37 [6.05-29.53] times more likely to be hospitalised/die from COVID-19 than individuals without conditions. We also show a dose-dependent association between post-vaccination antibody levels and COVID-19 hospitalisation or death, with those with undetectable antibody levels at a significantly higher risk (HR 9.21 [95% CI 4.63-18.29]) of these serious outcomes compared to those with high antibody levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Vaccines Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: NPJ Vaccines Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido