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NOVEL SIMPLEXVIRUS (SIMPLEXVIRUS DOLICHOTINEALPHA1) ASSOCIATED WITH FATALITY IN FOUR PATAGONIAN MARA (DOLICHOTIS PATAGONUM).
Freeman, Megan E; Goe, Alexandra; Ferguson, Sylvia H; Lee, Jung Keun; Struthers, Jason D; Buczek, Jennifer; Black, Annalise; Childress, April L; Armién, Anibal G; West, Gary; Wellehan, James F X.
Afiliación
  • Freeman ME; Phoenix Zoo, Phoenix, AZ 85008, USA, mfreeman@phoenixzoo.org.
  • Goe A; Department of Pathology, College of Veterinary Medicine, Midwestern University, Glendale, AZ 84308, USA.
  • Ferguson SH; Department of Pathology, College of Veterinary Medicine, Midwestern University, Glendale, AZ 84308, USA.
  • Lee JK; Department of Pathology, College of Veterinary Medicine, Midwestern University, Glendale, AZ 84308, USA.
  • Struthers JD; Department of Pathology, College of Veterinary Medicine, Midwestern University, Glendale, AZ 84308, USA.
  • Buczek J; Department of Pathology, College of Veterinary Medicine, Midwestern University, Glendale, AZ 84308, USA.
  • Black A; Department of Pathology, College of Veterinary Medicine, Midwestern University, Glendale, AZ 84308, USA.
  • Childress AL; Department of Comparative, Diagnostic & Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
  • Armién AG; Davis Branch, California Animal Health and Food Safety Laboratory System, University of California, Davis, CA 95617, USA.
  • West G; Phoenix Zoo, Phoenix, AZ 85008, USA.
  • Wellehan JFX; Department of Comparative, Diagnostic & Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608, USA.
J Zoo Wildl Med ; 55(2): 490-501, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38875207
ABSTRACT
Four of seven Patagonian maras (Dolichotis patagonum) at a zoological institution developed acute neurologic signs that progressed to tetraparesis and death. All affected were young adult females (10 mon-5 yr old) that presented over 11 d. Clinical signs were rapidly progressive and unresponsive to supportive therapies. Two of the four individuals were found deceased 4 d after hospitalization. Two individuals were euthanized due to poor prognosis and decline after 6 and 8 d, respectively. Simultaneously, an additional mara developed mild and self-resolving clinical signs, including a kyphotic gait and paraparesis. On gross examination, there were widespread petechiae and ecchymoses of the skeletal muscle, myocardium, skin, pericardium, urinary bladder mucosa, and spinal cord. On histopathology, all animals had necrotizing myelitis and rhombencephalitis, with intranuclear viral inclusions in three individuals. Electron microscopy confirmed herpesviral replication and assembly complexes in neurons and oligodendrocytes. Consensus PCR performed on spinal cord, brainstem, or cerebellum revealed a novel Simplexvirus most closely related to Simplexvirus leporidalpha 4. The virus was amplified and sequenced and is referred to as Simplexvirus dolichotinealpha1. It is unknown whether this virus is endemic in Patagonian mara or whether it represents an aberrant host species. Clinicians should be aware of this virus and its potential to cause severe, rapidly progressive, life-threatening disease in this species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Animales de Zoológico Límite: Animals Idioma: En Revista: J Zoo Wildl Med Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Animales de Zoológico Límite: Animals Idioma: En Revista: J Zoo Wildl Med Asunto de la revista: MEDICINA VETERINARIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos