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Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians.
Mahsoub, Nancy; Almenshawy, Ahmed; Taki Eldin, Ahmed Mohammad; Abdel Hay, Nehal M; Youssef, Amany R; El-Farahaty, Reham M; El-Sayed, Kefaya; Osman, Adel Mohamad; Elhennawy, Eman S.
Afiliación
  • Mahsoub N; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Almenshawy A; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Taki Eldin AM; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Abdel Hay NM; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Youssef AR; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • El-Farahaty RM; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • El-Sayed K; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Osman AM; Department of Cardiology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Elhennawy ES; Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. eman_elhenawy@mans.edu.eg.
Mol Biol Rep ; 51(1): 752, 2024 Jun 14.
Article en En | MEDLINE | ID: mdl-38874786
ABSTRACT

BACKGROUND:

Many studies have focused on the significance of lipid regulatory genes in the pathophysiology of Coronary artery disease (CAD). ApoB XbaI (rs693) and EcoRI (rs1042031) single nucleoid polymorphisms (SNPs) were investigated to detect whether they are risk factors for CAD. Till now, this association remains uncertain. SMARCA4 (rs1122608) SNP has directly related to dyslipidemia. Loss of function mutations (LOF) in PCSK9 result in a reduction in LDL cholesterol and are associated with protection from the development of CAD.

METHODS:

This study was conducted on 54 CAD patients who were admitted at Internal Medicine Specialized Hospital (Cardiology Department) and 47 healthy controls. Peripheral blood samples were taken from both groups. DNA was extracted from EDTA-blood samples, then PCR- RFLP for ApoB XbaI (rs693) and EcoRI (rs1042031), SMARCA4 (rs1122608) and PCSK9 (rs505151) SNPs was done.

RESULTS:

No statistically significant difference was found between patients and controls as regard EcoRI SNP. XbaI (rs693) X + X + genotype was significantly higher in control group (P = 0.0355). SMARCA4 (TT, GT + TT) genotypes, and T allele (P < 0.001); PCSK9 AG genotype and G allele (P = 0.027 and 0.032 respectively) were more frequent in CAD patients than controls.

CONCLUSION:

SMARCA4 (rs1122608) and PCSK9 (rs505151) SNPs are significantly accompanying with the risk of CAD development in the Egyptian population. X + X + genotype appeared to have a protective effect against CAD. However, no observed association between EcoRI (rs1042031) and the risk of CAD development was found.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Receptores de LDL / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Proproteína Convertasa 9 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Mol Biol Rep Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Receptores de LDL / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Proproteína Convertasa 9 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Mol Biol Rep Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Países Bajos