Rhodium(III)-Catalyzed Oxidative Cross-Coupling of <i>N</i>-Pyrimidylindoles with Cyclic ß-Keto Esters for Accessing All-Carbon Quaternary Centers.

Ding, Zhiying; Fu, Zhenda; Mi, Ruijie; Li, Xingwei

Rhodium(III)-Catalyzed Oxidative Cross-Coupling of N-Pyrimidylindoles with Cyclic ß-Keto Esters for Accessing All-Carbon Quaternary Centers.

Ding, Zhiying; Fu, Zhenda; Mi, Ruijie; Li, Xingwei.

Afiliación

Ding Z; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao, 266237, P. R. China.
Fu Z; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao, 266237, P. R. China.
Mi R; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao, 266237, P. R. China.
Li X; Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao, 266237, P. R. China.

Org Lett ; 26(25): 5295-5299, 2024 Jun 28.

Article en En | MEDLINE | ID: mdl-38874590

ABSTRACT

ABSTRACT

Rh(III)-catalyzed direct oxidative C-H/C-H cross-coupling between N-pyrimidylindoles and ß-ketoesters is presented. Easily available ß-ketoesters are used as an alkylating agent for the facile construction of all-carbon quaternary centers under mild conditions. The ester group in the product can undergo decarboxylation or decarboxylative amination.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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