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Pooled-analysis of tadalafil and tamsulosin for ureteral calculi.
Sun, Fengze; Liu, Hongquan; Wu, Gang; Liu, Ming; Liu, Shangjing; Wang, Lin; Zou, Qingsong; Cui, Yuanshan; Wu, Jitao.
Afiliación
  • Sun F; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Liu H; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Wu G; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Liu M; The Second Clinical Medical College, Binzhou Medical University, Yantai, Shandong, China.
  • Liu S; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Wang L; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Zou Q; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Cui Y; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
  • Wu J; Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China.
Front Pharmacol ; 15: 1351312, 2024.
Article en En | MEDLINE | ID: mdl-38873423
ABSTRACT

Objective:

Urolithiasis is a common urological diseases and affects the daily life of patients. Medical expulsive therapy has become acceptable for many parents. We conducted a meta-analysis to determine the efficacy and safety of tadalafil compared with tamsulosin for treating distal ureteral stones less than 10 mm in length.

Methods:

Related studies were identified via searches of the PubMed, Embase, and Cochrane Library databases. All the articles that described the use of tadalafil and tamsulosin for treating distal ureteral stones were collected.

Results:

A total of 14 studies were included in our meta-analysis. Our results revealed that tadalafil enhanced expulsion rate [odds ratio (OR) = 0.68, 95% confidence interval (CI) 0.47 to 0.98, p = 0.04]; reduced expulsion time [mean difference (MD) = 1.22, 95% CI (0.13, 2.30), p = 0.03]; lowered analgesia use [MD = 38.66, 95% CI (7.56, 69.77), p = 0.01] and hospital visits [MD = 0.14, 95% CI (0.06, 0.22), p = 0.0006]. According to our subgroup analysis, either tadalafil 5 mg or 10 mg did not promote expulsion rate and accelerate expulsion time compared with tamsulosin. But patients receiving 5 mg tadalafil decreased analgesia usage [MD = 101.04, 95% CI (67.56, 134.01), p < 0.00001].

Conclusion:

Compared with tamsulosin, tadalafil demonstrates a higher expulsion rate and less expulsion time for patients with distal ureteral stones less than 10 mm with a favorable safety profile.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza