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Whole-genome resequencing reveals genetic diversity, differentiation, and selection signatures of yak breeds/populations in southwestern China.
Zhang, Shilin; Li, Jing; Zhao, Yanhua; Tang, Yujun; Li, Hao; Song, Tianzeng; An, Tianwu; Guan, Jiuqiang; Li, Xiaowei; Zhang, Ming.
Afiliación
  • Zhang S; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
  • Li J; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
  • Zhao Y; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
  • Tang Y; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
  • Li H; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
  • Song T; Institute of Animal Science, Tibet Academy of Agricultural and Animal Husbandry Science, Lhasa, China.
  • An T; Sichuan Academy of Grassland Science, Chengdu, China.
  • Guan J; Sichuan Academy of Grassland Science, Chengdu, China.
  • Li X; Breeding Fram of Longri, Agriculture and Rural Bureau of Aba Prefecture in Sichuan, Hongyuan, China.
  • Zhang M; College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, China.
Front Genet ; 15: 1382128, 2024.
Article en En | MEDLINE | ID: mdl-38873117
ABSTRACT
The Sichuan-Yunnan region is the main production area of yaks in southwestern China, with rich genetic resources of Yaks. Nevertheless, there have been limited study on the genetic characteristics of the entire yak populations in Tibet and southwestern China. In this study, we performed whole-genome resequencing to identify genetic variation information in a total of 198 individuals from six yak breeds (populations) in Sichuan (Muli yak, Jinchuan yak, Changtai yak, Maiwa yak), Yunnan (Zhongdian yak), and Tibet (Tibetan yak). The aim was to investigate the whole-genome genetic diversity, population genetic structure, and genome selection signatures. We observed that all six populations exhibit abundant genetic diversity. Except for Tibetan yaks, which showed low nucleotide diversity (0.00104), the remaining yak populations generally displayed high nucleotide diversity (0.00129-0.00153). Population genetic structure analysis revealed that, among the six yak populations, Muli yak exhibited greater differentiation from other yak populations and formed a distinct cluster independently. The Maiwa yak population displayed a complex genetic structure and exhibited gene exchange with Jinchuan and Changtai yaks. Positive selection signals were detected in candidate genes associated with growth (GNB4, HMGA2, TRPS1, and LTBP1), reproduction (PI4KB, DYNC1I1, and GRIP1), immunity (CD200 and IL1RAP), lactation (SNX13 and CPM), hypoxia adaptation (NDUFB6, PRKN, and MRPS9), hair (KRT24, KRT25, and KRT26), meat quality (SUCLG2), digestion and absorption (CLDN1), and pigment deposition (OCA2) using the integrated Pi and F ST methods. This study provides significant insights into understanding the whole-genome genetic characteristics of yak populations in Tibet and southwestern China.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza