Your browser doesn't support javascript.
loading
Association of myosteatosis with short-term outcomes in patients with acute-on-chronic liver failure.
Geng, Nan; Kong, Ming; Zhang, Jiateng; Chen, Huina; Xu, Manman; Song, Wenyan; Chen, Yu; Duan, Zhongping.
Afiliación
  • Geng N; Department of Infectious Diseases, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
  • Kong M; Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, NO.8 Xitou Tiao Road Youwai Street, Beijing, 100069, China.
  • Zhang J; Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, NO.8 Xitou Tiao Road Youwai Street, Beijing, 100069, China.
  • Chen H; Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, NO.8 Xitou Tiao Road Youwai Street, Beijing, 100069, China.
  • Xu M; Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, NO.8 Xitou Tiao Road Youwai Street, Beijing, 100069, China.
  • Song W; Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
  • Chen Y; Department of Clinical Epidemiology and Clinical Trial, Capital Medical University, Beijing, 100069, China.
  • Duan Z; Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, NO.8 Xitou Tiao Road Youwai Street, Beijing, 100069, China.
Sci Rep ; 14(1): 13609, 2024 06 13.
Article en En | MEDLINE | ID: mdl-38871846
ABSTRACT
Sarcopenia (low muscle mass, i.e., quantity) is associated with poor clinical outcomes in patients with acute-on-chronic liver failure (ACLF). In this study, we aimed to illustrate the clinical prognostic value of myosteatosis (muscle fat infiltration) for short-term mortality in patients with ACLF. We retrospectively enrolled consecutive patients with ACLF between January 2019 and January 2022. Computed tomography-based body composition analysis was performed at the third lumbar vertebral level to determine skeletal muscle radiation attenuation. Fine and Gray's competing risk regression model, with liver transplantation as a competing risk, was used to assess the factors associated with 90-day mortality. A total of 431 patients with ACLF were included. Myosteatosis and sarcopenia were observed in 261 (60.6%) and 87 (20.2%) patients, respectively. Competitive risk regression showed that age (HR 1.021, 95% CI 1.000-1.043, P = 0.042), APASL ACLF Research Consortium (AARC) score (HR 1.498, 95% CI 1.312-1.710, P < 0.001), and sarcopenia (HR 1.802, 95% CI 1.062-3.060, P = 0.029) were independently associated with increased 90-day mortality. Subgroup analysis of male patients with HBV-ACLF revealed that myosteatosis (HR 2.119, 95% CI 1.101-4.078, P = 0.025) was promising prognostic factors for 90-day mortality after being adjusted for ascites, acute kidney injury, AARC score, and sarcopenia. Myosteatosis is predictive of short-term outcomes in male patients with HBV-ACLF. Our results emphasise the importance of focusing on muscle fat infiltration in patients with HBV-ACLF. Further studies are warranted to investigate the underlying mechanisms and potential therapies for myosteatosis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcopenia / Insuficiencia Hepática Crónica Agudizada Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcopenia / Insuficiencia Hepática Crónica Agudizada Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido