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Dietary NO3- does not enhance endothelial dependent cutaneous vascular conductance in older women.
Baranauskas, Marissa N; Blechschmid, Tyler H; Long, Emily B; Coggan, Andrew R; Carter, Stephen J.
Afiliación
  • Baranauskas MN; Department of Human Physiology & Nutrition, University of Colorado, Colorado Springs, CO, United States of America. Electronic address: mbaranau@uccs.edu.
  • Blechschmid TH; Department of Kinesiology, School of Public Health, Bloomington, IN, United States of America.
  • Long EB; Department of Kinesiology, School of Public Health, Bloomington, IN, United States of America.
  • Coggan AR; Department of Kinesiology, Indiana University Indianapolis, Indianapolis, IN, United States of America; Indiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, United States of America.
  • Carter SJ; Department of Kinesiology, School of Public Health, Bloomington, IN, United States of America.
Microvasc Res ; 155: 104706, 2024 09.
Article en En | MEDLINE | ID: mdl-38871050
ABSTRACT
Prior work has yet to determine whether the reduction of dietary nitrate (NO3-) to NO, via the enterosalivary pathway, may modify cutaneous vascular conductance (CVC) responses to local heating in older women. Changes occurring with the transition to menopause related to hormonal flux, increased adiposity, and/or decreased physical activity may further compound the negative influence of aging on nitric oxide (NO)-dependent CVC. Herein, we characterized changes in NO-dependent CVC following acute ingestion of 140 mL of NO3--rich beetroot juice in 24 older women (age 65 ± 5 y, BMI 31.2 ± 3.7 kg/m2). Red blood cell (RBC) flux was measured continuously via laser-Doppler flowmetry on the dorsal aspect of the forearm during local skin heating to 39 °C/44 °C before and 3 h after NO3- ingestion. NO-dependent changes in CVC were calculated as RBC flux/mean arterial blood pressure at 39 °C and normalized as a proportion of maximal CVC at 44 °C (%CVCmax). Changes (Δ) in fractional exhaled NO (FeNO) following NO3- ingestion were used an index of NO bioavailability. Despite increased FeNO (+81 ± 70 %, P < 0.001), %CVCmax at 39 °C was reduced (-16 ± 10 %, P < 0.001) following NO3- ingestion. A greater reduction in %CVCmax was weakly to moderately associated with higher body fat% (r = 0.45 [0.05-0.72], P = 0.029), central adiposity% (r = 0.50 [0.13-0.75], P = 0.012), neutrophil% (r = 0.42 [0.02-0.70], P = 0.041), and higher neutrophil to lymphocyte ratio (r = 0.49 [0.11-0.75], P = 0.016). These findings demonstrate a single dose of dietary NO3- does not promote CVC responses to local heating in sedentary older women with overweight and obesity. Correlation with multiple biomarkers suggest systemic inflammation may be involved.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Sanguíneo Regional / Piel / Beta vulgaris / Nitratos / Óxido Nítrico Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Microvasc Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flujo Sanguíneo Regional / Piel / Beta vulgaris / Nitratos / Óxido Nítrico Límite: Aged / Female / Humans / Middle aged Idioma: En Revista: Microvasc Res Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos