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Reliability and validity of cough peak flow measurements in myasthenia gravis.
Kuroiwa, Ryota; Shibuya, Kazumoto; Inagaki, Takeshi; Nara, Takeru; Nemoto, Marie; Doi, Yuka; Yasuda, Manato; Uzawa, Akiyuki; Shiko, Yuki; Murata, Atsushi; Yamanaka, Yoshitaka; Kuwabara, Satoshi.
Afiliación
  • Kuroiwa R; Division of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan. Electronic address: pseudoarthrosis7@chiba-u.jp.
  • Shibuya K; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Inagaki T; Division of Physical Therapy, Department of Rehabilitation, Faculty of Health Science, Chiba Prefectural University of Health Sciences, Chiba, Japan.
  • Nara T; Division of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Nemoto M; Division of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan.
  • Doi Y; Department of Rehabilitation Therapy, Chiba Rehabilitation Center, Chiba, Japan.
  • Yasuda M; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Uzawa A; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Shiko Y; Department of Biostatistics Section, Chiba University Hospital, Clinical Research Center, Chiba, Japan.
  • Murata A; Division of Rehabilitation Medicine, Chiba University Hospital, Chiba, Japan.
  • Yamanaka Y; Urayasu Rehabilitation Education Center, Chiba University Hospital, Chiba, Japan.
  • Kuwabara S; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Neuromuscul Disord ; 41: 29-34, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38870650
ABSTRACT
Decreased cough strength in myasthenia gravis (MG) leads to aspiration and increases the risk of MG crisis. The aim of this study was to clarify the reliability and validity of cough peak flow (CPF) measurements in MG. A total of 26 patients with MG who underwent CPF measurements using the peak flow meter by themselves were included. MG symptoms were evaluated by pulmonary function tests and clinical MG assessment scales before and after immune-treatments. The relationship between CPF and pulmonary function tests and MG comprehensive were assessed. The cut-off value of CPF for aspiration risk was determined and the area under the curve (AUC) was calculated. The intraclass correlation coefficient was more than 0.95 for pre-and post-treatment. Positive correlations were found between CPF and almost all spirometric values as well as between the differences of pre-and post-treatment in CPF and quantitative myasthenia gravis score. The CPF for identifying the aspiration risk was used to calculate the CPF cut-off value of 205 L/min with a sensitivity of 0.77, specificity of 0.90, and AUC of 0.85. The CPF, a convenient measure by patients themselves, has a high reliability in patients with MG, and is a useful biomarker reflecting MG symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tos / Miastenia Gravis Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neuromuscul Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tos / Miastenia Gravis Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neuromuscul Disord Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido