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Outcomes following gel-based autologous chondrocyte implantation for articular cartilage defects of the knee.
Pardiwala, Dinshaw N; Tapasvi, Sachin; Chaudhary, Deepak; Babhulkar, Ashish; Varghese, Jacob; Rajan, David; Narvekar, Abhay; Sancheti, Parag.
Afiliación
  • Pardiwala DN; Department of Centre for Bone and Joint, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India. Electronic address: pardiwala@outlook.com.
  • Tapasvi S; Department of Orthopaedic, The Orthopaedic Specialty Clinic, Pune, India. Electronic address: stapasvi@gmail.com.
  • Chaudhary D; Department of Centre for Arthroscopy and Sports Medicine, BLK-Max Super Speciality Hospital, New Delhi, India. Electronic address: deepakchaudhary@hotmail.com.
  • Babhulkar A; Department of Shoulder and Sports Injuries, Deenanath Mangeshkar Hospital, Pune, India. Electronic address: docshoulder@gmail.com.
  • Varghese J; Senior Consultant and HOD, Director of Orthopedics and Department of Joint Replacement & Sports Medicine, VPS Lakeshore Hospital, Kochi, India. Electronic address: varjac@gmail.com.
  • Rajan D; Department of Orthopaedic, Ortho One Orthopaedic Speciality Centre, Coimbatore, India. Electronic address: davidvrajan@gmail.com.
  • Narvekar A; Department of Centre for Orthopedic Care, P.D. Hinduja Hospital, Mumbai, India. Electronic address: narvekar72@gmail.com.
  • Sancheti P; Department of Joint Replacement, Sancheti Institute for Orthopaedics & Rehabilitation, Pune, India. Electronic address: parag@sanchetihospital.org.
Knee ; 49: 70-78, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38870617
ABSTRACT

BACKGROUND:

Gel-based autologous chondrocyte implantation (GACI) enables a simpler and more effective delivery of chondrocytes with reproducible three-dimensional structural restoration of the articular cartilage surface. There is limited documentation of medium-term outcomes. This study assessed safety and effectiveness of GACI for treatment of cartilage defects of the knee.

METHODS:

This multicentric retrospective study was conducted across eight hospitals in India. Patients who had undergone GACI (CARTIGROW®) between 2008 and 2014 for the treatment of focal articular cartilage defects of the knee (mean defect size 4.5 ± 5.8 cm2) in limbs with normal alignment were analyzed. Primary outcomes were changes in Lysholm Knee Scoring Scale score, and Knee Outcome Sports Activity Scale (SAS).

RESULTS:

A total of 107 patients (110 knee joints) with mean age 31.0 ± 10.5 years were included. The mean follow-up was 9.8 ± 1.5 years (range 7.85-13.43). Majority had osteochondritis dissecans (n = 51; 46.4%). The mean Lysholm Knee Scoring Scale score (81.23 ± 13.21 vs. 51.32 ± 17.89; p < 0.0001) and SAS score (80.93 ± 8.26 vs. 28.11 ± 12.28; p < 0.0001) improved significantly at follow-up as compared to pre-operative. Magnetic Resonance Observation of Cartilage Repair Tissue score in 39 patients at minimum 2 years follow-up was 84.5 ± 4.3. Among 30 patients who were playing sports before treatment, 17 patients (56.7%) could return to the same or higher level of sports post-transplantation. No major intra-operative or post-operative complications were noted. Four patients warranted revision surgery.

CONCLUSION:

GACI is an effective treatment option for large focal articular cartilage defects of the knee with a low complication rate and revision rate and significant improvement in functional scores.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante Autólogo / Cartílago Articular / Condrocitos / Articulación de la Rodilla Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Knee Asunto de la revista: ORTOPEDIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante Autólogo / Cartílago Articular / Condrocitos / Articulación de la Rodilla Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Knee Asunto de la revista: ORTOPEDIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos