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Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes.
Orsenigo, Federica; Stewart, Alexander; Hammer, Clare P; Clarke, Emma; Simpkin, Daniel; Attia, Hossameldin; Rockall, Timothy; Gordon, Siamon; Martinez, Fernando O.
Afiliación
  • Orsenigo F; Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK.
  • Stewart A; Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK; Virology Department, Animal and Plant Health Agency, APHA-Weybridge, KT15 3NB Addlestone, UK.
  • Hammer CP; Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK; Royal Surrey County Hospital NHS Foundation Trust, GU2 7XX Guildford, UK.
  • Clarke E; Royal Surrey County Hospital NHS Foundation Trust, GU2 7XX Guildford, UK.
  • Simpkin D; Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK.
  • Attia H; Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK; Royal Surrey County Hospital NHS Foundation Trust, GU2 7XX Guildford, UK.
  • Rockall T; Royal Surrey County Hospital NHS Foundation Trust, GU2 7XX Guildford, UK.
  • Gordon S; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan; Sir William Dunn School of Pathology, University of Oxford, OX13RE Oxford, UK.
  • Martinez FO; Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, UK. Electronic address: f.martinezestrada@surrey.ac.uk.
Cell Rep ; 43(6): 114352, 2024 Jun 25.
Article en En | MEDLINE | ID: mdl-38870011
ABSTRACT
Addressing the mononuclear phagocyte system (MPS) and macrophage M1/M2 activation is important in diagnosing hematological disorders and inflammatory pathologies and designing therapeutic tools. CSF1R is a reliable marker to identify all circulating MPS cells and tissue macrophages in humans using a single surface protein. CSF1R permits the quantification and isolation of monocyte and dendritic cell (DC) subsets in conjunction with CD14, CD16, and CD1c and is stable across the lifespan and sexes in the absence of overt pathology. Beyond cell detection, measuring M1/M2 activation in humans poses challenges due to response heterogeneity, transient signaling, and multiple regulation steps for transcripts and proteins. MPS cells respond in a conserved manner to M1/M2 pathways such as interleukin-4 (IL-4), steroids, interferon-γ (IFNγ), and lipopolysaccharide (LPS), for which we propose an ad hoc modular gene expression tool. Signature analysis highlights macrophage activation mosaicism in experimental samples, an emerging concept that points to mixed macrophage activation states in pathology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos / Activación de Macrófagos / Macrófagos Límite: Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Factor Estimulante de Colonias de Granulocitos y Macrófagos / Activación de Macrófagos / Macrófagos Límite: Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos