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Unveiling the natural history of paralysis in metastatic cervical spinal tumor: An experimental study.
Sato, Shunsuke; Takahashi, Masahito; Satomi, Kazuhiko; Ohne, Hideaki; Takeuchi, Takumi; Hasegawa, Atsushi; Ichimura, Shoichi; Hosogane, Naobumi.
Afiliación
  • Sato S; Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan.
  • Takahashi M; Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan.
  • Satomi K; Orthopaedic Surgery, Mitaka Hospital, Tokyo, Japan.
  • Ohne H; Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan.
  • Takeuchi T; Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan.
  • Hasegawa A; Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan.
  • Ichimura S; Orthopaedic Surgery, Kyorin University Suginami Hospital, Tokyo, Japan.
  • Hosogane N; Department of Orthopaedic Surgery, Kyorin University, Tokyo, Japan.
Brain Spine ; 4: 102842, 2024.
Article en En | MEDLINE | ID: mdl-38868600
ABSTRACT

Introduction:

Despite the relatively low prevalence of metastatic cervical spinal tumor, these entities give rise to more profound complications than thoracic and lumbar spinal tumor. However, it is regrettable that experimental investigation has thus far shown a dearth of attention to metastatic cervical spinal tumor. Research question What is the conceptualization and realization of quadriparesis resulting from metastatic cervical spinal tumor? Material and

methods:

Using Fischer 344 rats as the experimental cohort, this study orchestrated the engraftment of tumor cells procured from the 13762 MAT B III cell line (RRID CVCL_3475), which represents mammary adenocarcinoma. These cells were engrafted into the vertebrae of the cervical spine. A comprehensive inquiry encompassing behavioral assessments, histological evaluations, and microangiographic analyses conducted after the aforementioned cellular transplantation was subsequently pursued.

Results:

The incidence of cervical paralysis was 61.1%. Notably, the evolution of paralysis was unfurled by two distinctive temporal phases within its natural history. A meticulous histological examination facilitated delineation of the tumor's posterior expansion within the spinal canal. Simultaneously, the tumor exhibited anterior and lateral encroachment on the spinal cord, inducing compression from all sides. Augmented by microangiographic investigations, conspicuous attenuation of stained blood vessels within the affected anterior horn and funiculus of the spinal cord was observed. Discussion and

conclusion:

The pathological advancement of paralysis stemming from metastatic cervical spinal tumor is now apprehended to unfurl through a biphasic phase. The initial phase is characterized by gradual unfurling spanning several days, juxtaposed against the second phase marked by swift and accelerated progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Spine Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Spine Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos