Your browser doesn't support javascript.
loading
Unraveling the hepatic stellate cells mediated mechanisms in aging's influence on liver fibrosis.
Wahid, Reham M; Hassan, Nancy Husseiny; Samy, Walaa; Abdelhadi, Amina A; Saadawy, Sara F; Elsayed, Sherein F; Seada, Sara G; Mohamed, Sara Refaee Abdo.
Afiliación
  • Wahid RM; Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Hassan NH; Human Anatomy and Embryology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Samy W; Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Abdelhadi AA; Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. aminaabdalhady@medicine.zu.edu.eg.
  • Saadawy SF; Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Elsayed SF; Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Seada SG; Medical Physiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Mohamed SRA; Tropical Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Sci Rep ; 14(1): 13473, 2024 06 12.
Article en En | MEDLINE | ID: mdl-38866800
ABSTRACT
Aging enhances numerous processes that compromise homeostasis and pathophysiological processes. Among these, activated HSCs play a pivotal role in advancing liver fibrosis. This research delved into how aging impacts liver fibrosis mechanisms. The study involved 32 albino rats categorized into four groups Group I (young controls), Group II (young with liver fibrosis), Group III (old controls), and Group IV (old with liver fibrosis). Various parameters including serum ALT, adiponectin, leptin, and cholesterol levels were evaluated. Histopathological analysis was performed, alongside assessments of TGF-ß, FOXP3, and CD133 gene expressions. Markers of fibrosis and apoptosis were the highest in group IV. Adiponectin levels significantly decreased in Group IV compared to all other groups except Group II, while cholesterol levels were significantly higher in liver fibrosis groups than their respective control groups. Group III displayed high hepatic expression of desmin, α-SMA, GFAP and TGF- ß and in contrast to Group I. Increased TGF-ß and FOXP3 gene expressions were observed in Group IV relative to Group II, while CD133 gene expression decreased in Group IV compared to Group II. In conclusion, aging modulates immune responses, impairs regenerative capacities via HSC activation, and influences adipokine and cholesterol levels, elevating the susceptibility to liver fibrosis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Células Estrelladas Hepáticas / Cirrosis Hepática Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Células Estrelladas Hepáticas / Cirrosis Hepática Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Reino Unido