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Preparation of chitosan-hyaluronic acid microcapsules and its dynamic release behavior analysis in a 3D-printed microchannel system: Exploration and verification.
Fei, Xuening; Liang, Dongchi; Zhao, Hongbin; Yang, Yanzi; Yin, Mingyang; He, Zhengkuan; Liu, Zunfeng; Fan, Xiaopeng.
Afiliación
  • Fei X; School of Science, Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, Tianjin Chengjian University, Tianjin 300384, China; School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China.
  • Liang D; School of Science, Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, Tianjin Chengjian University, Tianjin 300384, China.
  • Zhao H; School of Science, Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, Tianjin Chengjian University, Tianjin 300384, China; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai Univer
  • Yang Y; School of Science, Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, Tianjin Chengjian University, Tianjin 300384, China.
  • Yin M; School of Science, Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, Tianjin Chengjian University, Tianjin 300384, China.
  • He Z; School of Science, Tianjin Engineering Technology Center of Chemical Wastewater Source Reduction and Recycling, Tianjin Chengjian University, Tianjin 300384, China.
  • Liu Z; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin 300071, China.
  • Fan X; Rianlon Corporation, Tianjin 300480, China.
Int J Biol Macromol ; 273(Pt 1): 133031, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38866283
ABSTRACT
This research focuses on the challenges of efficiently constructing drug carriers and evaluating their dynamic release in vitro simulation. By using pickering emulsion and layer-by-layer self-assembly methods. The microcapsules had tea tree oil as the core material, SiO2 nanoparticles as stabilizers, and chitosan and hyaluronic acid as shell materials. The microencapsulation mechanism, as well as the effects of core-shell mass ratio and stirring, were discussed. Specifically, a dynamic circulation simulation microchannel system was designed and manufactured based on 3D printing technology. In this simulation system, the release rate of microcapsules is accelerated and the trend changes, with its behavior aligning with the Boltzmann model. The study demonstrates the advantages of self-assembled inorganic-organic drug-loaded microcapsules in terms of controllable fabrication and ease of functional modification, and shows the potential of 3D printed cyclic microchannel systems in terms of operability and simulation fidelity in drug and physiological analysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cápsulas / Quitosano / Liberación de Fármacos / Impresión Tridimensional / Ácido Hialurónico Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cápsulas / Quitosano / Liberación de Fármacos / Impresión Tridimensional / Ácido Hialurónico Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos