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High circulating concentrations of estradiol are anabolic for bone mass and strength in an adult male to female transgender mouse model.
Venkatesh, Varun S; Nie, Tian; Golub, Suzanne; Stok, Kathryn S; Hemmatian, Haniyeh; Desai, Reena; Handelsman, David J; Zajac, Jeffrey D; Grossmann, Mathis; Davey, Rachel A.
Afiliación
  • Venkatesh VS; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia; Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia. Electronic address: varun.venkatesh@unimelb.edu.au.
  • Nie T; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia. Electronic address: tnie@student.unimelb.edu.au.
  • Golub S; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia. Electronic address: golubs@unimelb.edu.au.
  • Stok KS; Department of Biomedical Engineering, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: kathryn.stok@unimelb.edu.au.
  • Hemmatian H; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia. Electronic address: haniyeh.hemmatian@unimelb.edu.au.
  • Desai R; ANZAC Research Institute, University of Sydney and Andrology, Concord Repatriation General Hospital, Concord, New South Wales 2137, Australia. Electronic address: reena.desai@sydney.edu.au.
  • Handelsman DJ; ANZAC Research Institute, University of Sydney and Andrology, Concord Repatriation General Hospital, Concord, New South Wales 2137, Australia. Electronic address: djh@sydney.edu.au.
  • Zajac JD; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia. Electronic address: j.zajac@unimelb.edu.au.
  • Grossmann M; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia; Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia. Electronic address: mathisg@unimelb.edu.au.
  • Davey RA; Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria 3084, Australia. Electronic address: r.davey@unimelb.edu.au.
Bone ; 186: 117143, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38866125
ABSTRACT
The effects of gender affirming hormone therapy (GAHT) on bone microarchitecture and fracture risk in adult transgender women is unclear. To investigate the concept that skeletal integrity and strength in trans women may be improved by treatment with a higher dose of GAHT than commonly prescribed, we treated adult male mice with a sustained, high dose of estradiol. Adult male mice at 16 weeks of age were administered ~1.3 mg estradiol by silastic implant, implanted intraperitoneally, for 12 weeks. Controls included vehicle treated intact females and males. High-dose estradiol treatment in males stimulated the endocortical deposition of bone at the femoral mid-diaphysis, increasing cortical thickness and bone area. This led to higher stiffness, maximum force, and the work required to fracture the bone compared to male controls, while post-yield displacement was unaffected. Assessment of the material properties of the bone showed an increase in both elastic modulus and ultimate stress in the estradiol treated males. Treatment of male mice with high dose estradiol was also anabolic for trabecular bone, markedly increasing trabecular bone volume, number and thickness in the distal metaphysis which was accompanied by an increase in the histomorphometric markers of bone remodelling, mineralizing surface/bone surface, bone formation rate and osteoclast number. In conclusion, a high dose of estradiol is anabolic for cortical and trabecular bone in a male to female transgender mouse model, increasing both stiffness and strength. These findings suggest that increasing the current dose of GAHT administered to trans women, while considering other potential adverse effects, may be beneficial to preserving their bone microstructure and strength.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estradiol Límite: Animals / Female / Humans / Male Idioma: En Revista: Bone Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estradiol Límite: Animals / Female / Humans / Male Idioma: En Revista: Bone Asunto de la revista: METABOLISMO / ORTOPEDIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos