Your browser doesn't support javascript.
loading
Wnt signaling couples G2 phase control with differentiation during hematopoiesis in Drosophila.
Goins, Lauren M; Girard, Juliet R; Mondal, Bama Charan; Buran, Sausan; Su, Chloe C; Tang, Ruby; Biswas, Titash; Kissi, Jessica A; Banerjee, Utpal.
Afiliación
  • Goins LM; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: lgoins@stanford.edu.
  • Girard JR; Department of Biology, University of Massachusetts Boston, Boston, MA, USA.
  • Mondal BC; Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, India.
  • Buran S; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Su CC; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Tang R; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Biswas T; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Kissi JA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
  • Banerjee U; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA,
Dev Cell ; 59(18): 2477-2496.e5, 2024 Sep 23.
Article en En | MEDLINE | ID: mdl-38866012
ABSTRACT
During homeostasis, a critical balance is maintained between myeloid-like progenitors and their differentiated progeny, which function to mitigate stress and innate immune challenges. The molecular mechanisms that help achieve this balance are not fully understood. Using genetic dissection in Drosophila, we show that a Wnt6/EGFR-signaling network simultaneously controls progenitor growth, proliferation, and differentiation. Unlike G1-quiescence of stem cells, hematopoietic progenitors are blocked in G2 phase by a ß-catenin-independent (Wnt/STOP) Wnt6 pathway that restricts Cdc25 nuclear entry and promotes cell growth. Canonical ß-catenin-dependent Wnt6 signaling is spatially confined to mature progenitors through localized activation of the tyrosine kinases EGFR and Abelson kinase (Abl), which promote nuclear entry of ß-catenin and facilitate exit from G2. This strategy combines transcription-dependent and -independent forms of both Wnt6 and EGFR pathways to create a direct link between cell-cycle control and differentiation. This unique combinatorial strategy employing conserved components may underlie homeostatic balance and stress response in mammalian hematopoiesis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Fase G2 / Proteínas de Drosophila / Drosophila melanogaster / Vía de Señalización Wnt / Hematopoyesis Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Fase G2 / Proteínas de Drosophila / Drosophila melanogaster / Vía de Señalización Wnt / Hematopoyesis Límite: Animals Idioma: En Revista: Dev Cell Asunto de la revista: EMBRIOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos