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Comparison of the Efficacy of Omalizumab and Mepolizumab in Non-Steroidal Anti-Inflammatory Drug-Exacerbated Respiratory Disease.
Cihanbeylerden, Melek; Tuncay, Gülseren; Kayikçi, Hazal; Damadoglu, Ebru; Karakaya, Gül; Kalyoncu, Ali Fuat.
Afiliación
  • Cihanbeylerden M; Department of Chest Diseases, Division of Allergy and Clinical Immunology, Hacettepe University, School of Medicine, Ankara, Turkey.
  • Tuncay G; Department of Chest Diseases, Division of Allergy and Clinical Immunology, Hacettepe University, School of Medicine, Ankara, Turkey.
  • Kayikçi H; Department of Chest Diseases, Division of Allergy and Clinical Immunology, Hacettepe University, School of Medicine, Ankara, Turkey.
  • Damadoglu E; Department of Chest Diseases, Division of Allergy and Clinical Immunology, Hacettepe University, School of Medicine, Ankara, Turkey.
  • Karakaya G; Department of Chest Diseases, Division of Allergy and Clinical Immunology, Hacettepe University, School of Medicine, Ankara, Turkey.
  • Kalyoncu AF; Department of Chest Diseases, Division of Allergy and Clinical Immunology, Hacettepe University, School of Medicine, Ankara, Turkey.
Int Arch Allergy Immunol ; 185(10): 947-952, 2024.
Article en En | MEDLINE | ID: mdl-38865992
ABSTRACT

INTRODUCTION:

Non-steroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is heterogeneous in both phenotypes and endotypes. Due to insufficient head-to-head comparison studies, it is hard to decide which biological to initiate. This study aimed to compare the efficacy of omalizumab and mepolizumab which can be used in the treatment of patients with severe eosinophilic asthma diagnosed with N-ERD.

METHODS:

The population of this observational, cross-sectional study comprised of N-ERD patients who received omalizumab or mepolizumab for at least 6 months for severe asthma. Outcomes included the asthma control test (ACT), and sino-nasal outcome test scores (SNOT-22), blood eosinophil counts at initiation of biological treatment (T0, baseline) and at the end of 6th months (T6). Adverse effects related to biological treatment and changes of oral corticosteroids dose was recorded.

RESULTS:

The study included a total of 22 patients, of whom 11 received mepolizumab and 11 received omalizumab. The change in ACT, SNOT-22, eosinophil counts, and adverse effects related to biologicals were similar at T6 (p = 0.606, p = 0.168, p = 0.05, p = 0.053, respectively). However, when examining the SNOT-22 and ACT based on the cumulative distribution curve (SUCRA), mepolizumab (SUCRA value 0.61, 0.72, respectively) demonstrated greater efficacy compared to omalizumab (SUCRA value 0.19, 0.35, respectively). The oral corticosteroids discontinuation rate was similar between the two groups (p = 0.05).

CONCLUSION:

We found both omalizumab and mepolizumab to be effective in treatment; however, we determined that mepolizumab may have a potential superiority in efficacy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiasmáticos / Anticuerpos Monoclonales Humanizados / Omalizumab Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiasmáticos / Anticuerpos Monoclonales Humanizados / Omalizumab Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Suiza