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Aging and putative frailty biomarkers are altered by spaceflight.
Camera, Andrea; Tabetah, Marshall; Castañeda, Veronica; Kim, JangKeun; Galsinh, Aman Singh; Haro-Vinueza, Alissen; Salinas, Ivonne; Seylani, Allen; Arif, Shehbeel; Das, Saswati; Mori, Marcelo A; Carano, Anthony; de Oliveira, Lorraine Christine; Muratani, Masafumi; Barker, Richard; Zaksas, Victoria; Goel, Chirag; Dimokidis, Eleni; Taylor, Deanne M; Jeong, Jisu; Overbey, Eliah; Meydan, Cem; Porterfield, D Marshall; Díaz, Juan Esteban; Caicedo, Andrés; Schisler, Jonathan C; Laiakis, Evagelia C; Mason, Christopher E; Kim, Man S; Karouia, Fathi; Szewczyk, Nathaniel J; Beheshti, Afshin.
Afiliación
  • Camera A; Intitute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  • Tabetah M; Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, 47907, USA.
  • Castañeda V; Faculty of Medicine, Universidad de los Andes, Santiago, Chile.
  • Kim J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
  • Galsinh AS; School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB24 3FX, UK.
  • Haro-Vinueza A; Biología, Colegio de Ciencias Biológicas y Ambientales COCIBA, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
  • Salinas I; Escuela de Medicina, Colegio de Ciencias de La Salud COCSA, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
  • Seylani A; Riverside-School of Medicine, University of California, Riverside, CA, USA.
  • Arif S; Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Das S; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Mori MA; Atal Bihari Vajpayee Institute of Medical Sciences, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
  • Carano A; Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas, Campinas, SP, Brazil.
  • de Oliveira LC; Obesity and Comorbidities Research Center (OCRC), Universidade Estadual de Campinas, Campinas, SP, Brazil.
  • Muratani M; Ohio Musculoskeletal and Neurological Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, 45701, USA.
  • Barker R; Blue Marble Space Institute of Science, Seattle, WA, USA.
  • Zaksas V; Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
  • Goel C; Transborder Medical Research Center, University of Tsukuba, Ibaraki, 305-8575, Japan.
  • Dimokidis E; Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki, 305-8575, Japan.
  • Taylor DM; Department of Botany, University of Wisconsin-Madison, Madison, WI, USA.
  • Jeong J; Center for Translational Data Science, University of Chicago, Chicago, IL, 60637, USA.
  • Overbey E; Clever Research Lab, Springfield, IL, 62704, USA.
  • Meydan C; Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
  • Porterfield DM; Amazon Web Services, Osaka, Kita Ward, Japan.
  • Díaz JE; Department of Biomedical and Health Informatics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19041, USA.
  • Caicedo A; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Schisler JC; Translational-Transdisciplinary Research Center, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea.
  • Laiakis EC; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
  • Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
  • Kim MS; Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, 47907, USA.
  • Karouia F; Data Science Institute, School of Business, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
  • Szewczyk NJ; Instituto de Investigaciones en Biomedicina iBioMed, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
  • Beheshti A; Mito-Act Research Consortium, Quito, Ecuador.
Sci Rep ; 14(1): 13098, 2024 06 11.
Article en En | MEDLINE | ID: mdl-38862573
ABSTRACT
Human space exploration poses inherent risks to astronauts' health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth. However, our understanding of the connection between these molecular shifts and disease development in space remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated during spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA's GeneLab, along with astronaut data gathered from the JAXA and Inspiration4 missions. Our objective was to assess the presence of biological markers and pathways related to frailty, aging, and sarcopenia within the spaceflight context. Through our analysis, we identified notable changes in gene expression patterns that may be indicative of the development of a frailty-like condition during space missions. These findings suggest that the parallels between spaceflight and the aging process may extend to encompass frailty as well. Consequently, further investigations exploring the utility of a frailty index in monitoring astronaut health appear to be warranted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vuelo Espacial / Envejecimiento / Biomarcadores / Fragilidad Límite: Animals / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vuelo Espacial / Envejecimiento / Biomarcadores / Fragilidad Límite: Animals / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido