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Biomimetic Non-ergodic Aging by Dynamic-to-covalent Transitions in Physical Hydrogels.
Sen, Samya; Dong, Changxin; D'Aquino, Andrea I; Yu, Anthony C; Appel, Eric A.
Afiliación
  • Sen S; Department of Materials Science & Engineering, Stanford University, Stanford, California 94305, United States.
  • Dong C; Department of Materials Science & Engineering, Stanford University, Stanford, California 94305, United States.
  • D'Aquino AI; Department of Materials Science & Engineering, Stanford University, Stanford, California 94305, United States.
  • Yu AC; Department of Materials Science & Engineering, Stanford University, Stanford, California 94305, United States.
  • Appel EA; Department of Materials Science & Engineering, Stanford University, Stanford, California 94305, United States.
ACS Appl Mater Interfaces ; 16(25): 32599-32610, 2024 Jun 26.
Article en En | MEDLINE | ID: mdl-38862125
ABSTRACT
Hydrogels are soft materials engineered to suit a multitude of applications that exploit their tunable mechanochemical properties. Dynamic hydrogels employing noncovalent, physically cross-linked networks dominated by either enthalpic or entropic interactions enable unique rheological and stimuli-responsive characteristics. In contrast to enthalpy-driven interactions that soften with increasing temperature, entropic interactions result in largely temperature-independent mechanical properties. By engineering interfacial polymer-particle interactions, we can induce a dynamic-to-covalent transition in entropic hydrogels that leads to biomimetic non-ergodic aging in the microstructure without altering the network mesh size. This transition is tuned by varying temperature and formulation conditions such as pH, which allows for multivalent tunability in properties. These hydrogels can thus be designed to exhibit either temperature-independent metastable dynamic cross-linking or time-dependent stiffening based on formulation and storage conditions, all while maintaining structural features critical for controlling mass transport, akin to many biological tissues. Such robust materials with versatile and adaptable properties can be utilized in applications such as wildfire suppression, surgical adhesives, and depot-forming injectable drug delivery systems.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos