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Differences in characteristics and outcomes of older patients hospitalized for COVID-19 after introduction of vaccination.
Smits, Rosalinde A L; van Raaij, Bas F M; Trompet, Stella; van der Linden, Carolien M J; van der Bol, Jessica M; Jansen, Steffy W M; Polinder-Bos, Harmke A; Willems, Hanna C; van de Glind, Esther M M; Minnema, Julia; Tap, Lisanne; Mooijaart, Simon P.
Afiliación
  • Smits RAL; Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. r.a.l.smits@lumc.nl.
  • van Raaij BFM; Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
  • Trompet S; Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
  • van der Linden CMJ; Department of Geriatrics, Catharina Hospital, Eindhoven, The Netherlands.
  • van der Bol JM; Department of Geriatric Medicine, Reinier de Graaf Hospital, Delft, The Netherlands.
  • Jansen SWM; Department of Geriatrics, Catharina Hospital, Eindhoven, The Netherlands.
  • Polinder-Bos HA; Department of Internal Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
  • Willems HC; Section Geriatrics, Department of Internal Medicine, Amsterdam University Medical Centre, Location AMC, Amsterdam, The Netherlands.
  • van de Glind EMM; Department of Geriatrics, Alrijne Hospital, Leiderdorp, The Netherlands.
  • Minnema J; Department of Internal Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
  • Tap L; Department of Internal Medicine, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands.
  • Mooijaart SP; Section Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Eur Geriatr Med ; 15(4): 941-949, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38861241
ABSTRACT

PURPOSE:

The aim of the present study was to investigate characteristics and outcomes in vaccinated and unvaccinated older patients hospitalized for COVID-19 infection.

METHODS:

A retrospective multicentre cohort study among patients aged ≥70 years hospitalized for COVID-19 infection.

RESULTS:

263 vaccinated and 82 unvaccinated patients were included. Vaccinated patients were older (median age 79 vs. 76 years; p < 0.001), more patients were male (66.2% vs. 53.7%; p = 0.040), had more comorbidities [median Charlson Comorbidity Index (CCI) 2 vs. 1; p 0.016] and were frailer [Clinical Frailty Scale (CFS) ≥ 4 68% vs. 49%; p 0.015]. Vaccinated patients were admitted earlier after symptom onset (median 5 days vs. 7 days) but were equally ill at time of hospital admission. After correction for frailty, comorbidity and disease severity, risk of in-hospital mortality was three times lower for vaccinated patients (HR 0.30 95% CI 0.16-0.56; p < 0.001) compared to unvaccinated patients.

CONCLUSION:

Vaccinated patients had lower risk of in-hospital mortality than unvaccinated patients with COVID-19 infection. These findings suggest that vaccinated patients benefit from the protective effect of the vaccine against death during hospital stay, outweighing the increased mortality risk that is associated with older age, greater frailty and more numerous comorbidities. This could be an encouragement for older people to receive age-appropriate vaccines, although no definite conclusions can be drawn for this was no intervention study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comorbilidad / Mortalidad Hospitalaria / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Hospitalización Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Eur Geriatr Med Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comorbilidad / Mortalidad Hospitalaria / Vacunas contra la COVID-19 / SARS-CoV-2 / COVID-19 / Hospitalización Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Eur Geriatr Med Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Suiza