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Arterial function in response to a 50 km ultramarathon in recreational athletes.
Ranadive, Sushant M; Weiner, Cynthia M; Eagan, Lauren E; Addison, Odessa; Landers-Ramos, Rian Q; Prior, Steven J.
Afiliación
  • Ranadive SM; Department of Kinesiology, University of Maryland, College Park, Maryland, USA.
  • Weiner CM; Department of Kinesiology, University of Maryland, College Park, Maryland, USA.
  • Eagan LE; Department of Kinesiology, University of Maryland, College Park, Maryland, USA.
  • Addison O; Department of Physical Therapy and Rehabilitation Science, University of Maryland, Baltimore, Maryland, USA.
  • Landers-Ramos RQ; Department of Veterans Affairs and Veterans Affairs Medical Center, Geriatric Research, Education and Clinical Center, Baltimore, Maryland, USA.
  • Prior SJ; Department of Kinesiology, Towson University, Towson, Maryland, USA.
Exp Physiol ; 109(8): 1385-1394, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38860912
ABSTRACT
This study was performed to determine whether prolonged endurance running results in acute endothelial dysfunction and wave-reflection, as endothelial dysfunction and arterial stiffness are cardiovascular risk factors. Vascular function (conduit artery/macrovascular and resistance artery/microvascular) was assessed in 11 experienced runners (8 males, 3 females) before, during and after a 50 km ultramarathon. Blood pressure (BP), heart rate (HR), wave reflection, augmentation index (AIx) and AIx corrected for HR (AIx75) were taken at all time points-Baseline (BL), following 10, 20, 30 and 40 km, 1 h post-completion (1HP) and 24 h post-completion (24HP). Flow-mediated dilatation (FMD) and inflammatory biomarkers were examined at BL, 1HP and 24HP. Reactive hyperaemia area under the curve (AUC) and shear rate AUC to peak dilatation were lower (∼75%) at 1HP compared with BL (P < 0.001 for both) and reactive hyperaemia was higher at 24HP (∼27%) compared with BL (P = 0.018). Compared to BL, both mean central systolic BP and mean central diastolic BP were 7% and 10% higher, respectively, following 10 km and 6% and 9% higher, respectively, following 20 km, and then decreased by 5% and 8%, respectively, at 24HP (P < 0.05 for all). AIx (%) decreased following 20 km and following 40 km compared with BL (P < 0.05 for both) but increased following 40 km when corrected for HR (AIx75) compared with BL (P = 0.02). Forward wave amplitude significantly increased at 10 km (15%) compared with BL (P = 0.049), whereas backward wave reflection and reflected magnitude were similar at all time points. FMD and baseline diameter remained similar. These data indicate preservation of macrovascular (endothelial) function, but not microvascular function resulting from the 50 km ultramarathon.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Endotelio Vascular / Atletas / Frecuencia Cardíaca Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Exp Physiol Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Endotelio Vascular / Atletas / Frecuencia Cardíaca Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Exp Physiol Asunto de la revista: FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido