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Merging DNA Repair with Bioorthogonal Conjugation Enables Accessible and Versatile Asymmetric DNA Catalysis.
Sheng, Jie; Li, Zhaoyang; Koh, Kelly Kar Yun; Shi, Qi; Foo, Angel; Tan, Philip Mark Leetiong; Kha, Tuan-Khoa; Wang, Xujie; Fang, Leonard; Zhu, Ru-Yi.
Afiliación
  • Sheng J; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Li Z; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Koh KKY; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Shi Q; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Foo A; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Tan PML; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Kha TK; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Wang X; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Fang L; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
  • Zhu RY; Department of Chemistry, National University of Singapore, Singapore 117544, Singapore.
J Am Chem Soc ; 2024 Jun 11.
Article en En | MEDLINE | ID: mdl-38860598
ABSTRACT
Optimizing catalysts through high-throughput screening for asymmetric catalysis is challenging due to the difficulty associated with assembling a library of catalyst analogues in a timely fashion. Here, we repurpose DNA excision repair and integrate it with bioorthogonal conjugation to construct a diverse array of DNA hybrid catalysts for highly accessible and high-throughput asymmetric DNA catalysis, enabling a dramatically expedited catalyst optimization process, superior reactivity and selectivity, as well as the first atroposelective DNA catalysis. The bioorthogonality of this conjugation strategy ensures exceptional tolerance toward diverse functional groups, thereby facilitating the facile construction of 44 DNA hybrid catalysts bearing various unprotected functional groups. This unique feature holds the potential to enable catalytic modalities in asymmetric DNA catalysis that were previously deemed unattainable.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Am Chem Soc Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos