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The dynamic molecular characteristics of neutrophils are associated with disease progression in dengue patients.
Ou, Guanyong; Liu, Jiexiang; Zou, Rongrong; Gu, Yuchen; Niu, Shiyu; Yin, Juzhen; Yuan, Jing; Qu, Zhijun; Yang, Yang; Liu, Yingxia.
Afiliación
  • Ou G; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
  • Liu J; School of Medicine, Southern University of Science and Technology, Shenzhen, China.
  • Zou R; Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Gu Y; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
  • Niu S; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
  • Yin J; School of Medicine, Southern University of Science and Technology, Shenzhen, China.
  • Yuan J; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
  • Qu Z; School of Medicine, Southern University of Science and Technology, Shenzhen, China.
  • Yang Y; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
  • Liu Y; School of Medicine, Southern University of Science and Technology, Shenzhen, China.
J Med Virol ; 96(6): e29729, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38860590
ABSTRACT
Dengue, the most prevalent mosquito-borne disease worldwide, poses a significant health burden. This study integrates clinical data and transcriptomic datasets from different phases of dengue to investigate distinctive and shared cellular and molecular features. Clinical data from 29 dengue patients were collected and analyzed alongside a public transcriptomic data set (GSE28405) to perform differential gene expression analysis, functional enrichment, immune landscape assessment, and development of machine learning model. Neutropenia was observed in 54.79% of dengue patients, particularly during the defervescence phase (65.79%) in clinical cohorts. Bioinformatics analyses corroborated a significant reduction in neutrophil immune infiltration in dengue patients. Receiver operating characteristic curve analysis demonstrated that dynamic changes in neutrophil infiltration levels could predict disease progression, especially during the defervescence phase, with the area under the curve of 0.96. Three neutrophil-associated biomarkers-DHRS12, Transforming growth factor alpha, and ZDHHC19-were identified as promising for diagnosing and predicting dengue progression. In addition, the activation of neutrophil extracellular traps was significantly enhanced and linked to FcγR-mediated signaling pathways and Toll-like receptor signaling pathways. Neutrophil activation and depletion play a critical role in dengue's immune response. The identified biomarkers and their associated pathways offer potential for improved diagnosis and understanding of dengue pathogenesis and progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Progresión de la Enfermedad / Dengue / Neutrófilos Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Med Virol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Progresión de la Enfermedad / Dengue / Neutrófilos Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Med Virol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos